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Study on induction of the totipotent embryo-stem cells from human bone marrow mesenchymal stem cells

Research Project

Project/Area Number 24592867
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionOkayama University

Principal Investigator

IZAWA Shunji  岡山大学, 医歯(薬)学総合研究科, 助教 (20273998)

Co-Investigator(Renkei-kenkyūsha) YOSHIYAMA Masahiro  岡山大学, 大学院医歯薬学総合研究科, 教授 (10201071)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords骨髄間葉系幹細胞 / 脂肪由来幹細胞 / 免疫賦活因子 / 環境因子 / 細胞の初期化 / ES細胞 / 組織再生 / ES細胞 / 全能性 / 胚性幹細胞(ES細胞) / 胚性幹細胞・ES細胞
Outline of Final Research Achievements

Based on our past results that bone marrow mesenchymal stem cells keep potential totipotency and activate tissue-specific totipotency by stimulation of inflammatory cytokine, we planned the induction experiment of the totipotent / embryo-stem cells from bone marrow mesenchymal stem cells.
And as the results, it was suggested that the combination of TNF α and activin A factor is useful for the initialization of not only bone marrow mesenchymal stem cells but also adiose dirived stem cells. as for this fact, not only the regeneration of the tooth but also the whole body is enabled, and the significance is profound.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2014 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Study of Pluripotency and Activation of Totipotency in Human Bone Marrow Mesenchymal Stem Cells2012

    • Author(s)
      Shunji IZAWA, Kozo YAMAJI, Tomohiro HOSHIKA, Yoshihiro NISHITANI and Masahiro YOSHIYAMA
    • Journal Title

      Journal of Oral Tissue Engineering

      Volume: Vol.10 No.2 Pages: 95-103

    • NAID

      130004941084

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒト脂肪由来幹細胞を用いたES細胞の誘導に関する研究   ーエピジェネティック制御と細胞の初期化ー2014

    • Author(s)
      伊澤俊次, 山路公造, 星加知宏, 西谷佳浩, 吉山昌宏
    • Organizer
      第12回日本再生歯科医学会学術大会
    • Place of Presentation
      徳島
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト骨髄間葉系幹細胞を用いたES細胞の誘導に関する研究 ー免疫賦活因子および初期化因子の探索ー2012

    • Author(s)
      伊澤俊次, 山路公造, 星加知宏, 西谷佳浩, 吉山昌宏
    • Organizer
      日本再生歯科医学会
    • Place of Presentation
      ニチイ学会神戸ポートアイランドセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト骨髄間葉系幹細胞を用いたES細胞の誘導に関する研究   ーエピジェネティック制御と細胞の初期化ー

    • Author(s)
      伊澤俊次, 山路公造, 星加知宏, 西谷佳浩, 吉山昌宏
    • Organizer
      第11回日本再生歯科医学会 学術大会
    • Place of Presentation
      東京 日本大学理工学部1号館CSTホール
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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