Research Project
Grant-in-Aid for Scientific Research (C)
Various cytokines and growth factors induce wound healing during inflammatory responses. Wnts are known to enhance skin wound healing. In this study, we utilized gene-modified mice in which Wnts signal is prolonged during inflammatory responses. We experimentally exposed the molars of these mice to evoke pulpal tissue inflammation to analyze the importance of Wnt signal during pulpal tissue inflammation. The wound healing responses of pulpal tissues in the molars of these gene-modified mice were enhanced compared with that of control mice. The regenerated hard tissues in these gene-modified mice were morphologically bone-like structure and immunohistochemically dentin-like tissues. These results indicated the development of methods to enhance endogenous Wnt signal in pulpal tissues could be contribute for generating biological materials for direct pulp capping.
All 2015 2014 2012 Other
All Journal Article (4 results) (of which Peer Reviewed: 4 results, Open Access: 2 results) Presentation (2 results) (of which Invited: 1 results)
J Bone Miner Res.
Volume: in print Issue: 7 Pages: 1150-1159
10.1002/jbmr.2444
PLoS One
Volume: 9(11) Issue: 11 Pages: e112490-e112490
10.1371/journal.pone.0112490
The Japanese Journal of Conservative Dentistry
Volume: 57 Issue: 6 Pages: 547-554
10.11471/shikahozon.57.547
130005005966
Nephrol Dial Transplant.
Volume: 29 Pages: 611-8