| Project/Area Number |
24592890
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
ANAN Hisashi 福岡歯科大学, 歯学部, 教授 (80158732)
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| Co-Investigator(Kenkyū-buntansha) |
MOROTOMI Takahiko 九州歯科大学, 歯学部, 准教授 (10347677)
IZUMI Toshio 福岡歯科大学, 歯学部, 准教授 (40248547)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | PSリポソーム / 生体活性ガラス / BMP-2 / ALP / 骨形成 / 創傷治癒 / 再生医療 / μCT / 根尖性歯周炎 / マクロファージ / ハイドロキシアパタイト / 破骨細胞 / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
Periapical lesions were induced in the mandibular first molars of rats, and then PS liposomes (PSL) were applied to the exposed periapical tissues. In the PSL-treated rats, cells expressing BMP-2 rapidly increased in number, and newly formed reparative bone tissues showing strong alkaline phosphatase activity were observed earlier and larger in amount than that seen in the phosphate-buffered saline (PBS)-treated rats. It is suggested that PSL may create a favorable environment that promotes the healing of destroyed periapical tissues.
In addition, active new bone formation was observed in the bone defect with a combination of bioactive glass (BAG) and PS. The findings suggested that osteogenesis in bone cavities can be promoted through combined use of PSL and BAG.
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