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Investigation of the inhibitory factors in osseointegration for the clinical application.

Research Project

Project/Area Number 24592895
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthetic dentistry
Research InstitutionHokkaido University

Principal Investigator

HORIUCHI Rumi  北海道大学, 大学病院, 助教 (10374274)

Co-Investigator(Kenkyū-buntansha) HORIUCHI Msasataka  北海道医療大学, 薬学部, 講師 (90322825)
YOKOYAMA Atsuro  北海道大学, 大学院歯学研究科, 教授 (20210627)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywordsオッセオインテグレーション / マイクロアレイ / チタンインプラント
Outline of Final Research Achievements

In this study, we have set up the hypothesis that micro-movement by loose fit implant induces the expression of genes involved in preventing osseointegration. In order to identify the genes involved in micro-movement, we performed whole genome microarray analysis of the tissues around the titanium implants in a model rat of acquired and non-acquired osseointegration. The microarray data suggested the existence of the group of genes involved in bone formation induced from the success of osseointegration, while that of the group of genes involved in failure of osseointegration. To investigate the relationship between those gene products and success/failure of osseointegration, we produced proteins as the factors to ensure success of osseointegration and proteins as one of the factors to prevent osseointegration, by using GRP-tag affinity purification system .

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014

All Presentation (2 results)

  • [Presentation] オッセオインテグレーション獲得に関わるタンパク質の昆虫細胞を用いた生産2014

    • Author(s)
      堀内留美、堀内正隆、横山敦郎
    • Organizer
      平成26年度 日本補綴歯科学会 東北北海道支部学術大会
    • Place of Presentation
      市民交流プラザ(郡山市)
    • Year and Date
      2014-10-25 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Investigation of the inhibitory factors for osseointegration in the early stage of the implantation.2014

    • Author(s)
      Masataka Horiuchi, Rumi Horiuchi, Masanori Ochiai, Atsuro Yokoyama
    • Organizer
      The 28th Annual Symposium of The Protein Society
    • Place of Presentation
      Manchester Grand Hyatt (San Diego,USA)
    • Year and Date
      2014-07-27 – 2014-07-30
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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