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Research and development of a novel denture cleaning device utilizing a disinfection technique based on photolysis of hydrogen peroxide

Research Project

Project/Area Number 24592901
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthetic dentistry
Research InstitutionTohoku University

Principal Investigator

KANNO Taro  東北大学, 歯学研究科(研究院), 助教 (30302160)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsヒドロキシルラジカル / 義歯洗浄 / 過酸化水素 / 可視光照射
Outline of Final Research Achievements

In the present study, the bactericidal effect and influence on the denture base-resin of denture cleaning technique using a newly developed device based on photolysis of hydrogen peroxide were evaluated. The device consisted of ultrasound cleaning bath and high power LED. Bactericidal test showed that the photolysis of hydrogen peroxide killed Streptococcus mutans with a >5-log reduction of viable counts within 3 min. Regarding the influence of the cleaning technique on the resin material, it was found that the strength and color were affected as the irradiance of LED increased. However, the results suggest that the influence may be acceptable when the LED was used at an irradiance of 10 mW/cm2 even on the assumption of repeated denture cleanings.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (43 results)

All 2015 2014 2013 2012

All Journal Article (23 results) (of which Peer Reviewed: 22 results) Presentation (19 results) Book (1 results)

  • [Journal Article] Synergistic interaction between wavelength of light and concentration of H2O2 in bactericidal activity of photolysis of H2O2.2015

    • Author(s)
      Toki, T., Nakamura, K., Kurauchi, M., Kanno, T., Katsuda, Y., Ikai, H., Hayashi, E., Egusa, H., Sasaki, K., Niwano, Y.
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 19(3) Issue: 3 Pages: 1358-1362

    • DOI

      10.1016/j.jbiosc.2014.08.015

    • NAID

      210000004988

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postantifungal-like effect of sublethal treatment of Candida albicans with acid-electrolyzed water.2015

    • Author(s)
      Mokudai T, Kanno T, Niwano Y.
    • Journal Title

      Arch Oral Biol.

      Volume: 60 Issue: 3 Pages: 479-487

    • DOI

      10.1016/j.archoralbio.2014.12.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of reactive oxygen species in the cytotoxic effect of acid-electrolyzed water.2015

    • Author(s)
      Mokudai T, Kanno T, Niwano Y.
    • Journal Title

      J Toxicol Sci.

      Volume: 40 Pages: 13-19

    • NAID

      130004904021

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bactericidal Activity and Mechanism of Photoirradiated Polyphenols against Gram-Positive and -Negative Bacteria.2015

    • Author(s)
      Nakamura K, Ishiyama K, Sheng H, Ikai H, Kanno T, Niwano Y.
    • Journal Title

      J Agric Food Chem.

      Volume: 印刷中 Issue: 35 Pages: 7707-7713

    • DOI

      10.1021/jf5058588

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fracture resistance of monolithic zirconia molar crowns with reduced thickness.2015

    • Author(s)
      Nakamura K, Harada A, Inagaki R, Kanno T, Niwano Y, Milleding P, Örtengren U.
    • Journal Title

      Acta Odontol Scand.

      Volume: 30 Issue: 2 Pages: 1-7

    • DOI

      10.1111/eos.12173

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoprotective effect of short-term pretreatment with proanthocyanidin on human gingival fibroblasts exposed to harsh environmental conditions.2014

    • Author(s)
      Kurauchi M, Niwano Y, Shirato M, Kanno T, Nakamura K, Egusa H, Sasaki K.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 11 Pages: e113403-e113403

    • DOI

      10.1371/journal.pone.0113403

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acceleration of proliferative response of mouse fibroblasts by short-time pretreatment with polyphenols.2014

    • Author(s)
      Tsuruya, M., Niwano, Y., Nakamura, K., Kanno, T., Nakashima, T., Egusa, H., Sasaki, K.
    • Journal Title

      Applied Biochemistry and Biotechnology.

      Volume: 174(6) Issue: 6 Pages: 2223-2235

    • DOI

      10.1007/s12010-014-1124-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blue light injures corneal epithelial cells in the mitotic phase in vitro.2014

    • Author(s)
      Niwano Y, Kanno T, Iwasawa A, Ayaki M, Tsubota K
    • Journal Title

      Br J Ophthalmol.

      Volume: in press Issue: 7 Pages: 990-992

    • DOI

      10.1136/bjophthalmol-2014-305205

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Postantibiotic effect of disinfection treatment by photolysis of hydrogen peroxide.2014

    • Author(s)
      Odashima, Y., Nakamura, K., Ikai, H., Kanno, T., Meirelles, L., Sasaki, K., Niwano, Y.
    • Journal Title

      Journal of Chemotherapy

      Volume: 26(2): Issue: 2 Pages: 92-100

    • DOI

      10.1179/1973947813y.0000000114

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro evaluation of the risk of inducing bacterial resistance to disinfection treatment with photolysis of hydrogen peroxide2013

    • Author(s)
      Ikai, H., Odashima, Y., Kanno, T., Nakamura, K., Shirato, M., Sasaki, K., Niwano, Y
    • Journal Title

      PLoS ONE

      Volume: 8(11) Issue: 11 Pages: e81316-e81316

    • DOI

      10.1371/journal.pone.0081316

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synergistic effect of proanthocyanidin on the bactericidal action of the photolysis of H2O2.2013

    • Author(s)
      Ikai H, Nakamura K, Kanno T, Shirato M, Meirelles L, Sasaki K, Niwano Y.
    • Journal Title

      Biocontrol Sci.

      Volume: 18(3) Pages: 137-141

    • NAID

      10031202904

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of a new denture cleaning technique based on photolysis of H(2)O(2) the mechanical properties and color change of acrylic denture base resin.2013

    • Author(s)
      Nakahara T, Harada A, Yamada Y, Odashima Y, Nakamura K, Inagaki R, Kanno T, Sasaki K, Niwano Y.
    • Journal Title

      Dent Mater J.

      Volume: 32(4) Pages: 529-536

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro bactericidal activity of photo-irradiated oxydol products via hydroxyl radical generation.2013

    • Author(s)
      Oyamada A, Ikai H, Nakamura K, Hayashi E, Kanno T, Sasaki K, Niwano Y.
    • Journal Title

      Biocontrol Sci.

      Volume: 18(2) Pages: 83-88

    • NAID

      10031184509

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Photo-irradiation of proanthocyanidin as a new disinfection technique via reactive oxygen species formation2013

    • Author(s)
      Nakamura K, Shirato M, Ikai H, Kanno T, Sasaki K, Kohno M, Niwano Y.
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 3 Pages: e60053-e60053

    • DOI

      10.1371/journal.pone.0060053

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synergistic Effect of Proanthocyanidin on Bactericidal Action of the Photolysis of H2O22013

    • Author(s)
      Hiroyo Ikai, Keisuke Nakamura, Taro Kanno, Midori Shirato, Luiz Meirelles
    • Journal Title

      Bioscience Control

      Volume: in press

    • NAID

      10031202904

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] In Vitro Bactericidal Activity on Photo-irradiated Oxydol Products via Hydroxyl Radical Generation2013

    • Author(s)
      Akira Oyamada, Hiroyo Ikai, Keisuke Nakamura, Eisei Hayashi, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano
    • Journal Title

      Bioscience Control

      Volume: in press

    • NAID

      10031184509

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ラジカル殺菌技術の歯科応用2013

    • Author(s)
      菅野太郎、中村圭祐
    • Journal Title

      歯界展望

      Volume: 121(3) Pages: 514-521

    • Related Report
      2012 Research-status Report
  • [Journal Article] Corrosive effect of disinfection solution containing hydroxyl radicals generated by photolysis of H<sub>2</sub>O<sub>2</sub> on dental metals2012

    • Author(s)
      Nakamura K, Yamada Y, Takada Y, Mokudai T, Ikai H, Inagaki R, Kanno T, Sasaki K, Kohno M, Niwano Y
    • Journal Title

      Dental Materials Journal

      Volume: 31 Issue: 6 Pages: 941-946

    • DOI

      10.4012/dmj.2012-098

    • NAID

      10031126072

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Presence of hydrogen peroxide a source of hydroxyi radicals in acid electrolyzed water2012

    • Author(s)
      Mokudai T, Nakamura K, Kann T, Niwano Y
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 9 Pages: e46392-e46392

    • DOI

      10.1371/journal.pone.0046392

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bactericidal Action of Photoirradiated Gallic Acid via Reactive Oxygen Species Formation2012

    • Author(s)
      Nakamura K, Yamada Y, Ikai H, Kanno T, Sasaki K, Niwano Y.
    • Journal Title

      J Agric Food Chem

      Volume: 60 Pages: 10048-10054

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel denture-cleaning system based on hydroxyl radical disinfection.2012

    • Author(s)
      Kanno T, Nakamura K, Ikai H, Hayashi E, Shirato M, Mokudai T, Iwasawa A, Niwano Y, Kohno M, Sasaki K.
    • Journal Title

      Int J Prosthdont

      Volume: 25(4) Pages: 376-380

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo anti-Staphylococcus aureus activities of a new disinfection system utilizing photolysis of hydrogen peroxide2012

    • Author(s)
      Hayashi, E., Mokudai, T., Yamada, Y., Nakamura, K., Kanno, T., Sasaki, K., Niwano, Y
    • Journal Title

      J. Biosci. Bioeng

      Volume: 114(2) Issue: 2 Pages: 193-197

    • DOI

      10.1016/j.jbiosc.2012.03.020

    • NAID

      110009495428

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Topical treatment of oral cavity and wounded skin with a new disinfection system utilizing photolysis of hydrogen peroxide in rats.2012

    • Author(s)
      Yamada Y, Mokudai T, Nakamura K, Hayashi E, Kawana Y, Kanno T, Sasaki K, Niwano Y.
    • Journal Title

      J Toxicol Sci

      Volume: 37(2) Pages: 329-335

    • NAID

      10030126757

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 過酸化水素の光分解および水の超音波分解を併用したヒドロキシルラジカル生成系の殺菌効果2014

    • Author(s)
      生宏、中村圭祐、菅野太郎、佐々木啓一、庭野吉己
    • Organizer
      日本防菌防黴学会第41回年次大会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 過酸化水素光分解殺菌技術を応用した新規歯周病治療器の安全性と有効性の検証2014

    • Author(s)
      猪飼紘代,目代貴之,中村圭祐,菅野太郎,庭野吉己
    • Organizer
      日本防菌防黴学会第41回年次大会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 活性酸素2014

    • Author(s)
      中村圭祐,菅野太郎,猪飼紘代,庭野吉己
    • Organizer
      日本防菌防黴学会第41回年次大会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 過酸化水素光分解殺菌技術における光の波長と過酸化水素濃度の相乗作用2014

    • Author(s)
      倉内美智子,唐木英俊,中村圭祐,菅野太郎,勝田悠介,猪飼紘代,林栄成,佐々木啓一,庭野吉己
    • Organizer
      日本防菌防黴学会第41回年次大会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Candida albicansに対する希釈酸性電解水のpost-antifungal like effectと活性酸素の関与2014

    • Author(s)
      目代貴之,菅野太郎,庭野吉己
    • Organizer
      日本防菌防黴学会第41回年次大会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 酸性電解水の細胞毒性における活性酸素の関与2014

    • Author(s)
      庭野吉己,目代貴之,追泉里実,菅野太郎
    • Organizer
      日本防菌防黴学会第41回年次大会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Bactericidal effect of photolysis of H2O2 in combination with sonolysis of water via hydroxyl radical generation2014

    • Author(s)
      Sheng, H., Nakamura, K., Kanno, T., Sasaki, K., Niwano, Y.
    • Organizer
      5th International Symposium for Interface Oral Health Science
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] Acceleration of proliferative response of 3T3-L1 mouse fibroblasts and human gingival fibroblasts by short-term exposure to proanthocyanidin2014

    • Author(s)
      Kurauchi, M., Nakamura, K., Kanno, T., Shirato, M., Sasaki, K., Niwano, Y.
    • Organizer
      5th International Symposium for Interface Oral Health Science
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 過酸化水素光分解殺菌技術を応用した新規歯周病治療器の開発2013

    • Author(s)
      菅野太郎、中村圭祐、猪飼紘代、庭野吉己、佐々木啓一
    • Organizer
      日本歯周病学会2013春季学術大会(第56回)
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 歯垢染色剤に含まれる各種キサンテン系色素を光感受性物質とした一重項酸素依存性光線力学殺菌療法の比較2013

    • Author(s)
      庭野吉己、石山希里香、中村圭祐、猪飼紘代、菅野太郎、佐々木啓一
    • Organizer
      第23回日本光線力学学会学術講演会
    • Place of Presentation
      旭川
    • Related Report
      2013 Research-status Report
  • [Presentation] Advantages of new disinfection treatment utilizing photolysis of hydrogen peroxide2013

    • Author(s)
      Ikai, H., Odashima, Y., Nakamura, K., Shirato, M., Kanno, T., Sasaki, K., Niwano, Y
    • Organizer
      Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar
    • Place of Presentation
      宮城蔵王
    • Related Report
      2013 Research-status Report
  • [Presentation] Bactericidal action of photogenerated singlet oxygen from photosensitizers used in plaque disclosing agents2013

    • Author(s)
      Ishiyama, K., Nakamura, K., Ikai, H., Kanno, T., Sasaki, K., Niwano, Y.
    • Organizer
      Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar
    • Place of Presentation
      宮城蔵王
    • Related Report
      2013 Research-status Report
  • [Presentation] 電気分解で生成された酸性電解水中に存在する水酸化ラジカルは殺菌活性に寄与するか?2013

    • Author(s)
      目代貴之、中村圭祐、菅野太郎、庭野吉己
    • Organizer
      日本防菌防黴学会第40回年次大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 過酸化水素光分解殺菌法の耐性誘導試験2013

    • Author(s)
      猪飼紘代 、中村圭祐、小田島優、白土翠、菅野太郎、庭野吉己
    • Organizer
      日本防菌防黴学会第40回年次大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 過酸化水素光分解殺菌法の短時間処理が残存細菌に及ぼす増殖抑制効果2013

    • Author(s)
      小田島優、中村圭祐、猪飼紘代、菅野太郎、佐々木啓一、庭野吉己
    • Organizer
      日本防菌防黴学会第40回年次大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 各種ポリフェノールに対する青色可視光照射で得られる殺菌効果の比較検討2013

    • Author(s)
      中村圭祐、石山希里香、猪飼紘代、菅野太郎、庭野吉己
    • Organizer
      日本防菌防黴学会第40回年次大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] New Denture-Cleaning Device Utilizing Hydroxyl Radical Disinfection2012

    • Author(s)
      Taro Kanno, Keisuke Nakamura, Hiroyo Ikai, Midori Shirato, Takayuki Mokudai, Yoshimi Niwano and Keiichi Sasaki
    • Organizer
      International Workshop on Biomaterials in Biosis-Abiosis Intelligent Interface Science
    • Place of Presentation
      宮城・蔵王
    • Related Report
      2012 Research-status Report
  • [Presentation] 市販オキシドールの光分解殺菌効果2012

    • Author(s)
      小山田晃、猪飼紘代、中村圭祐、菅野太郎、佐々木啓一、庭野吉己
    • Organizer
      日本防菌防黴学会 第39回年次大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 過酸化水素光分解殺菌法に対する熱エネルギーの相乗的効果2012

    • Author(s)
      白土翠、猪飼紘代、中村圭祐、菅野太郎、佐々木啓一、庭野吉己
    • Organizer
      第22回日本歯科医学会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Book] CollectedEvidence: Case Reports コレクテッド エビデンス vol.32013

    • Author(s)
      弘岡秀明、菅野太郎
    • Total Pages
      201
    • Publisher
      デンタルダイヤモンド社
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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