Research and development of the dental material having a functional antibacterial action

• Project/Area Number: 24592917
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: NOMURA YUJI 広島大学, 医歯薬保健学研究院, 助教 (80218370)
• Co-Investigator(Kenkyū-buntansha): SAWAJIRI Masahiko 広島大学, 医歯薬保健学研究院, 助教 (20325195)
• Co-Investigator(Renkei-kenkyūsha): TAKAHASI Toru 熊本保健科学大学, 保健科学部, 教授 (70369122)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 機能的消毒作用 / 二酸化塩素 / 歯科材料 / 歯科器機

Outline of Final Research Achievements

The acid such as lactic acid which bacteria produces in the mouth is one of the cause of the dental caries. So we performed the development of the disinfectant and dental materials which acts effectively when bacteria was producing an acid. The one used for this study is an aqueous solution of chlorine dioxide. Chlorine dioxide possesses a wide antibacterial spectrum and strong sterilizing power on the very low concentration, and the safety to a living body is also high. Using this nature, the functional disinfectant and the dental materials have been developed which indicate the more strong sterilization effect when bacteria possessed an acid production.

Research Products

• [Journal Article] The extracts of Japanese willow tree species are effective for apoptotic desperation or differentiation of acute myeloid leukemia cells (2014)
  • Author(s): Kounosuke Fujita, Yuji Nomura1, Masahiko Sawajiri1, Pravat K. Mohapatra, Hany A. El-Shemy, Nguyen T. Nguyen, Masashi Hosokawa, Kazuo Miyashita, Teruo Maeda, Hirofumi Saneoka, Shohei Fujita, Takayuki Fujita
  • Journal Title: Pharmacognosy Magazine Volume: 10 Issue: 38 Pages: 125-131
  • DOI: 10.4103/0973-1296.131023
  • Peer Reviewed / Open Access
• [Presentation] 二 酸化塩素のC.albicans バイオフィルムに対する抗菌効果 (2012)
  • Author(s): 堀 智治，野 村 雄二，呉本 晃一，貞森 紳丞，赤川 安正
  • Organizer: 第121回日本補綴歯科学会学術大会
  • Place of Presentation: 横浜
• [Patent(Industrial Property Rights)] 二酸化ハロゲンを含む水溶液製造方法及び水蒸気発生装置 (2014)
  • Inventor(s): 野村雄二、澤尻昌彦
  • Industrial Property Rights Holder: 野村雄二、澤尻昌彦
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-113404
  • Filing Date: 2014-05-13