• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Risk assessment of prosthodontic treatment by peripheral benzodiazepine receptor gene polymorphism

Research Project

Project/Area Number 24592926
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthetic dentistry
Research InstitutionKyushu Dental College

Principal Investigator

MASAKI Chihiro  九州歯科大学, 歯学部, 助教 (60397940)

Co-Investigator(Kenkyū-buntansha) HOSOKAWA Ryuji  九州歯科大学, 歯学部, 教授 (60211546)
NAKAMOTO Tetusji  九州歯科大学, 歯学部, 准教授 (30514989)
KONDO Yusuke  九州歯科大学, 歯学部, 助教 (00611287)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords睡眠時ブラキシズム / 遺伝子多型
Outline of Final Research Achievements

Peripheral-type benzodiazepine receptor (PBR) gene polymorphism is associated with stress sensitivity, but it is not yet clear whether polymorphisms in this gene have any influence on psychological stress. The present study was performed to examine the relationship between sleep bruxism and PBR gene polymorphism. The PBR gene was amplified using phi29 DNA polymerase after collection of DNA from oral mucosa cells. We also measured masseter muscle activity during sleep using portable electromyography to evaluate sleep bruxism. Furthermore, stimulated whole-saliva samples were collected for quantification of salivary chromogranin A (CgA) level. Thirty-two subjects (68.1%) had the G/G genotype, 13 (27.6%) had G/A, and 2 had A/A. The number of bruxism events was significantly higher in the G/A than the G/G group. Changes in salivary CgA levels were significantly lower in the G/A than G/G group. PBR gene polymorphism may influence psychological stress management through bruxism during sleep.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Sleep bruxism is affected by peripheral benzodiazepine receptor gene polymorphisms2014

    • Author(s)
      Takaya Murakami, Chihiro Masaski, Hidetaka Takahashi, Michiko Makino, Taro Mukaibo, Yusuke Kondo, Tetsuji Nakamoto, Ryuji Hosokawa
    • Journal Title

      International journal of stomatology & occlusion medicine

      Volume: 7 Issue: 1 Pages: 13-17

    • DOI

      10.1007/s12548-013-0101-z

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi