Evaluation of osteoconductivity and biodegradation properties of collagen/ beta-tricalcium phosphate composite

• Project/Area Number: 24592932
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: SAKURAI Kaoru 東京歯科大学, 歯学部, 教授 (20153950)
• Co-Investigator(Kenkyū-buntansha): YAMADA Masahiro 東北大学大学院歯学研究科分子, 再生歯科補綴学分野, 講師 (90549982)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: alloplast / bio-absorption / bone regeneration / bone substitute / socket preservation / ridge augmentation / 骨再生 / リン酸三カルシウム / 骨芽細胞 / コラーゲン

Outline of Final Research Achievements

The objective of this study was to determine whether the beta-tricalcium phosphate (β-TCP)-collagen composite consisting of bovine dermis-derived soluble collagen sponge and porous β-TCP particles exerts excellent osteoconductive and biodegradation properties better than the existing inorganic/collagen composite for clinical use. Rat calvarial critical-sized bone defects implanted with the β-TCP-collagen composite covered with dense, continuous and mature bone tissue with nearly complete replacement of the graft material in contrast with limited amounts of immature trabecular bone and abundant remnant materials in the defects filled with the existing clinical composite material. The β-TCP-collagen composite exerted greater osteoconductivity and better biodegradation properties by enhancement of osteoblastic mineralization capability than the existing composite material.

Research Products

• [Journal Article] Ultraviolet-C irradiation to titanium implants increases peri-implant bone formation without impeding mineralization in a rabbit femur model. (2015)
  • Author(s): Yamazaki M, Yamada M, Ishizaki K, Sakurai K.
  • Journal Title: Acta Odontol Scand. Volume: 73 Issue: 4 Pages: 302-311
  • DOI: 10.3109/00016357.2014.956332
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] N-acetyl cysteine alleviates inflammatory reaction of oral epithelial cells to poly(methyl methacrylate) extract (2015)
  • Author(s): Nishimiya H, Yamada M, Ueda T, Sakurai K.
  • Journal Title: Acta Odontol Scand. Volume: 0000 Pages: 0000-0000
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Periodontal-like gingival connective tissue attachment on titanium surface with nano-ordered spikes and pores created by alkali-heat treatment. (2015)
  • Author(s): Kato E, Sakurai K, Yamada M.
  • Journal Title: Dent Mater. Volume: 0000 Issue: 5 Pages: 0000-0000
  • DOI: 10.1016/j.dental.2015.01.014
  • Peer Reviewed
• [Journal Article] Retrospective clinical outcome of nanopolymorphic crystalline hydroxyapatite-coated and anodic oxidized titanium implants for 10 years (2015)
  • Author(s): Kato E, Yamada M, Sakurai K.
  • Journal Title: Journal of Prosthodontic Research Volume: 59 Issue: 1 Pages: 62-70
  • DOI: 10.1016/j.jpor.2014.11.004
  • NAID: 130007936682
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed
• [Journal Article] Evaluation of application possibility of water containing organic acids for chemical denture cleaning for older adults. (2015)
  • Author(s): Izumi S, Ryu M, Ueda T, Ishihara K, Sakurai K.
  • Journal Title: Geriatr Gerontol Int. Volume: 000 Issue: 3 Pages: 000-000
  • DOI: 10.1111/ggi.12467
  • Peer Reviewed / Open Access
• [Journal Article] 超高齢社会に貢献し，会員が満足する学会に (2014)
  • Author(s): 櫻井 薫
  • Journal Title: 老年歯科医学 Volume: 29 Pages: 1-1
  • Peer Reviewed
• [Journal Article] 摂食・嚥下リハビリテーションの地域医療連携モデル―在宅でのVEを用いた摂食・嚥下障害の評価と胃エックス線装置のVF装置への応用― (2014)
  • Author(s): 齋藤貴之,原 豪志,山崎康弘,小林健一郎,繁里有希,若狭宏嗣,吉岡麻耶,吉田真由,渡邉真央,大屋喜章,櫻井 薫,戸原 玄
  • Journal Title: 老年歯科医学 Volume: 29 Pages: 42-46
  • NAID: 130004679687
  • Peer Reviewed
• [Journal Article] Association between frequency of oral and denture cleaning and personality in edentulous older adults. (2014)
  • Author(s): Ryu, M., Izumi, S., Ueda, T., Oda, S., Sakurai, K.
  • Journal Title: Geriatr Gerontol Int. Volume: 000 Issue: 12 Pages: 000-000
  • DOI: 10.1111/ggi.12423
  • Peer Reviewed
• [Journal Article] Influence of chewing time on salivary stress markers (2014)
  • Author(s): Tasaka, A., Takeuchi, K., Sasaki, H., Yoshii, T., Soeda, R., Ueda, T., Sakurai, K.
  • Journal Title: Journal of Prosthodontic Research Volume: 58 Issue: 1 Pages: 48-54
  • DOI: 10.1016/j.jpor.2013.10.005
  • NAID: 130004953487
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed
• [Journal Article] Expression and Localization of Aqua-glyceroporins AQP3 and AQP9 in Rat Oral Epitheria (2014)
  • Author(s): Poveda, M., Hashimoto, S., Enokiya, Y, Matsuki-Fukushima, M., Sasaki, H., Sakurai, K., Shimono, M.
  • Journal Title: The Bulletin of Tokyo Dental College Volume: 55 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Specific ultraviolet-C irradiation energy for functionalization of titanium surface to increase osteoblastic cellular attachment (2013)
  • Author(s): Uchiyama, H., Yamada, M., Ishizaki, K.,Sakurai, K.
  • Journal Title: J Biomater Appl. Volume: 28 Issue: 9 Pages: 1419-1429
  • DOI: 10.1177/0885328213511678
  • Peer Reviewed
• [Journal Article] Effect of swallowing exercises in independent elderly. (2013)
  • Author(s): Sugiyama T, Ohkubo M, Honda Y, Tasaka A, Nagasawa K, Ishida R, Sakurai K.
  • Journal Title: Bull Tokyo Dent Coll. Volume: 54 Pages: 109-15
  • NAID: 130004868680
  • Peer Reviewed
• [Journal Article] N-acetyl cysteine as an osteogenesis-anhancing molecule for bone regeneration (2013)
  • Author(s): Yamada M, Tsukimura N, Ikeda T, Sugita Y, Att W, Kojima N, Kubo K, Ueno T, Sakurai K, Ogawa T
  • Journal Title: Biomaterials Volume: 34(26) Issue: 26 Pages: 6147-6156
  • DOI: 10.1016/j.biomaterials.2013.04.064
  • Peer Reviewed
• [Journal Article] Discoloration of Ti-20Cr alloy in oral environment and its surface characterization. (2013)
  • Author(s): Takemoto S, Tasaka A, Hattori M, Sakurai K, Oda Y.
  • Journal Title: Dent Mater J. Volume: 31 Pages: 1060-7
  • NAID: 10031126090
  • Peer Reviewed
• [Journal Article] Reduction of biofilm formation on titanium surface with ultraviolet-C pre-irradiation. (2013)
  • Author(s): Yamada Y, Yamada M, Ueda T, Sakurai K.
  • Journal Title: J Biomater Appl. Volume: 0000 Issue: 2 Pages: 0-0
  • DOI: 10.1177/0885328213518085
  • Peer Reviewed
• [Journal Article] 可撤性補綴装置でメインテナンス時の対応を考慮した天然歯‐インプラント治療症例 (2013)
  • Author(s): 田坂彰規,古谷義隆,上田貴之,矢島安朝,櫻井 薫
  • Journal Title: 歯科学報 Volume: 113 Pages: 145-151
  • NAID: 10031175406
  • Peer Reviewed
• [Journal Article] Infraocclusion Treated with Removable Prosthesis on Occlusal Surface of Severely Attritioned Teeth (2013)
  • Author(s): Tasaka, A., Ueda, T., Sakurai, K.
  • Journal Title: International Journal of Prosthodontics and Restorative Dentistry Volume: 2 Issue: 2 Pages: 66-71
  • DOI: 10.5005/jp-journals-10019-1051
  • Peer Reviewed
• [Journal Article] Necessity to Consider Home-visit Dental Care on Prosthodontics (2013)
  • Author(s): Sakurai, K.
  • Journal Title: International Journal of Prosthodontics and Restorative Dentistry Volume: 2
  • Peer Reviewed
• [Journal Article] クラウンブリッジだけではもったいない！ 自動練和シリコーン印象材を用いた義歯の簡単印象法 (2013)
  • Author(s): 上田貴之,櫻井 薫
  • Journal Title: 歯界展望 Volume: 122 Pages: 338-342
• [Journal Article] 骨再生における多機能性分子としての抗酸化アミノ酸誘導体 (2013)
  • Author(s): 山田将博,小川隆広,櫻井 薫
  • Journal Title: 日本補綴歯科学会誌 Volume: 5 Pages: 411-413
  • NAID: 10031202888
• [Journal Article] Activation of Osteoblastic Differentiation through Calcium supplementation by Beta-Tricalcium Phosphate Collagen Composite Leading to Initial Inner Bone Formation (2013)
  • Author(s): Kato, E., Yamada, M., Sakurai, K.
  • Journal Title: 日本口腔インプラント学会誌 Volume: 26 Pages: 405-417
  • NAID: 130004631892
• [Journal Article] 臨床のヒントQ＆A35 有床義歯補綴系 総義歯の咬合採得手順と注意事項について教えてください。 (2013)
  • Author(s): 櫻井 薫
  • Journal Title: 歯科学報 Volume: 113 Pages: 62-64
  • Peer Reviewed
• [Journal Article] Development of New Attachment System with Soft Lining Material for Implant-retained Complete Denture (2013)
  • Author(s): Koike, T., Ueda, T., Noda, S., Ogami, K., Pravinkumar G Patil., Sakurai, K.
  • Journal Title: International Journal of Prosthodontics and Restorative Dentistry. Volume: 3 Issue: 1 Pages: 21-24
  • DOI: 10.5005/jp-journals-10019-1070
  • Peer Reviewed
• [Journal Article] Flexure Strength and Fatigue Durability of Ce-TZP/Al2O3 Nanocomposite with Different Sintering Process and Surface Treatment. (2013)
  • Author(s): Takano, T., Tasaka, A., Yoshinari, M., Sakurai, K.
  • Journal Title: International Journal of Prosthodontics and Restorative Dentistry. Volume: 3 Issue: 3 Pages: 92-95
  • DOI: 10.5005/jp-journals-10019-1084
• [Journal Article] Early-stage osseointegration capability of a submicrofeatured titanium surface created by microroughening and anodic oxidation (2013)
  • Author(s): Yamada M, Ueno T, Minamikawa H, Ikeda T, Nakagawa K, Ogawa T.
  • Journal Title: Clinical oral implant research Volume: 24(9) Issue: 9 Pages: 991-1001
  • DOI: 10.1111/j.1600-0501.2012.02507.x
  • Peer Reviewed
• [Journal Article] Biodegradation Property of Beta-Tricalcium Phosphate-Collagen Composite in Accordance with Bone Formation: A Comparative Study with Bio-Oss Collagen® in a Rat Critical-Size Defect Model. (2012)
  • Author(s): Kato, E., Lemler, J., Sakurai, K. and Yamada, M.
  • Journal Title: Clin Implant Dent Relat Res Volume: - Issue: 2 Pages: 202-211
  • DOI: 10.1111/j.1708-8208.2012.00467.x
  • Peer Reviewed
• [Journal Article] N-acetyl Cysteine Improves Affinity of Beta-Tricalcium Phosphate Granules for Cultured Osteoblast-like Cells (2012)
  • Author(s): Yamada M, Minamikawa H, Ueno T, Sakurai K, Ogawa T
  • Journal Title: J Biomater Appl. Volume: (In press) Issue: 1 Pages: 27-36
  • DOI: 10.1177/0885328210383598
  • Peer Reviewed
• [Journal Article] Fatigue Strength of Ce-TZP/Al2O3 Nanocomposite with Different Surfaces (2012)
  • Author(s): Takano, T., Tasaka, A., Yoshinari, M., Sakurai, K.
  • Journal Title: J Dent Res. Volume: 91 Issue: 8 Pages: 800-4
  • DOI: 10.1177/0022034512452277
  • Peer Reviewed
• [Presentation] Anti-Infection Capability of Antioxidant N-Acetyl-L-Cysteine for Prevention of Aspiration Pneumonia (2015)
  • Author(s): Koizumi, C., Yamada, M., Ueda, T., Ishizaki, K., Sakurai, K.
  • Organizer: 38th Annual Conference of the European Prosthodontic Association
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2015-09-25 – 2015-09-27
• [Presentation] Enhancing Osteoblastic Extracellular Matrix Formation on Titanium-Hydroxylapatite-Coated Micro-Roughened Surfaces (2015)
  • Author(s): Yamada, M., Nakazawa, M., Sakurai, K.
  • Organizer: 38th Annual Conference of the European Prosthodontic Association
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2015-09-25 – 2015-09-27
• [Presentation] Periodontal-like Connective Tissue Attachment on Cementum-mimetic Titanium Surface (2015)
  • Author(s): Yamada, M., Sakurai, K.
  • Organizer: 93rd General Session ＆ Exhibition of the IADR
  • Place of Presentation: Boston, USA
  • Year and Date: 2015-03-11 – 2015-03-14
• [Presentation] Satisfaction of Treatment-by Complete Denture Using CAD/CAM Technology (2015)
  • Author(s): Ryu M, Carlo PM, Sakurai, K.
  • Organizer: 87th Annual Meeting of The American Prothodontic Society
  • Place of Presentation: Chikago, USA
  • Year and Date: 2015-02-26 – 2015-02-27
• [Presentation] Comparison of Cyclie Fatigue Resistance of Commercially Pure Titanium between Grade 2 and Grade 4 (2015)
  • Author(s): Suzuki, K., Takano, T., Ueda, T., Yoshinari, M., Sakurai, K.
  • Organizer: 87th Annual Meeting of The American Prothodontic Society
  • Place of Presentation: Chikago, USA
  • Year and Date: 2015-02-26 – 2015-02-27
• [Presentation] Evaluation of Wearing Comfort with Zirconia Plate (2015)
  • Author(s): Wada, T., Takano, T., Tasaka, A., Ueda, T., Yoshinari, M., Sakurai, K.
  • Organizer: 87th Annual Meeting of The American Prothodontic Society
  • Place of Presentation: Chikago, USA
  • Year and Date: 2015-02-26 – 2015-02-27
• [Presentation] N-アセチルシステインはPMMAレジンの口腔粘膜上皮細胞に対する細胞為害性を消去する (2014)
  • Author(s): 西宮紘子,山田将博,上田貴之,櫻井 薫
  • Organizer: 日本補綴歯科学会東京支部総会・第18回学術大会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-09
• [Presentation] 洗口剤と口腔保湿剤を用いた要介護高齢者への口腔清掃による微生物数と湿潤度の変化 (2014)
  • Author(s): 小林健一郎,竜 正大,和泉佐知,上田貴之,櫻井 薫
  • Organizer: 洗口剤と口腔保湿剤を用いた要介護高齢者への口腔清掃による微生物数と湿潤度の変化
  • Place of Presentation: 東京
  • Year and Date: 2014-11-09
• [Presentation] 骨芽細胞増殖を活性化させるチタンアパタイトナノコーティング (2014)
  • Author(s): 中澤正博,山田将博,石崎 憲,上田貴之,櫻井 薫
  • Organizer: 日本補綴歯科学会東京支部総会・第18回学術大会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-09
• [Presentation] 軟質裏装材を応用したインプラントオーバーデンチャーのアタッチメントシステムの開発 (2014)
  • Author(s): 古池崇志,山田裕介,荻野崇真,高野智史,野田周太郎,吉井崇之,大神浩一郎,上田貴之,櫻井 薫
  • Organizer: 日本補綴歯科学会東京支部総会・第18回学術大会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-09
• [Presentation] Effect of Food Hardness on Autonomic Nervous Response in Elderly People (2014)
  • Author(s): Ohta, M., Ueda, T., Sakurai, K.
  • Organizer: Indonesian prosthodontic society and Japan Prosthodontic Society Joint Meeting,
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2014-10-30 – 2014-11-01
• [Presentation] Anti-bacterial adhesion effect of TiO2 coating on denture base resin (2014)
  • Author(s): Obata, T., Ueda, T., Sakurai, K.
  • Organizer: Indonesian prosthodontic society and Japan Prosthodontic Society Joint Meeting,
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2014-10-30 – 2014-11-01
• [Presentation] Durability and Adaptivity of a New Attachment System for Overdenture using a Soft Lining Material (2014)
  • Author(s): Koike, T., Yamada, Y., Takano, T., Noda, S., Yoshii, T., Ogami, K., Ueda, T., Sakurai, K.
  • Organizer: Indonesian prosthodontic society and Japan Prosthodontic Society Joint Meeting,
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2014-10-30 – 2014-11-01
• [Presentation] Investigation of Factors Affecting Expression of Antimicrobal Peptide Defensin on Oral Mucosal Epithelium. (2014)
  • Author(s): Ogami, K., Ryu, M., Uchiyama, H., Koike, T., Tomura, K., Ueda, T., Sakurai, K.
  • Organizer: Indonesian prosthodontic society and Japan Prosthodontic Society Joint Meeting,
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2014-10-30 – 2014-11-01
• [Presentation] 抗酸化アミノ酸誘導体を用いたヒト小気道上皮細胞の細菌性炎症反応と粘液過剰分泌の回避 (2014)
  • Author(s): 小泉ちあき,山田将博,上田貴之,石崎 憲,櫻井 薫
  • Organizer: 第298回東京歯科大学学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-18
• [Presentation] 高齢者における咀嚼運動の自律神経活動への影響 (2014)
  • Author(s): 太田 緑,上田貴之,櫻井 薫
  • Organizer: 第298回東京歯科大学学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-18
• [Presentation] 加熱重合および3Dプリンタで製作した義歯床の精度検証 (2014)
  • Author(s): 田坂彰規,松永 智,古池崇志,和田 健,石崎 憲,上田貴之,吉成正雄,櫻井 薫
  • Organizer: 第298回東京歯科大学学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-18
• [Presentation] 鼻咽腔閉鎖機能不全症例におけるCTデータを利用した顎義歯製作の試み (2014)
  • Author(s): 萩尾美樹，石崎 憲，山内智博，佐藤一道，野村武史，小林健一郎，髙野伸夫，櫻井 薫
  • Organizer: 日本顎顔面補綴学会第31回総会・学術大会
  • Place of Presentation: 仙台
  • Year and Date: 2014-06-21 – 2014-06-22
• [Presentation] 毛羽立ち状ナノ構造体チタン表面と結合組織線維との嵌合 (2014)
  • Author(s): 山田将博，石崎 憲，櫻井 薫
  • Organizer: 日本顎顔面補綴学会第31回総会・学術大会
  • Place of Presentation: 仙台
  • Year and Date: 2014-06-20 – 2014-06-21
• [Presentation] 歯面に付着したStreptococcus sanguinisとPorphyromonas gingivalisに対する有機酸含有機能水の除菌効果 (2014)
  • Author(s): 梅澤朋子,竜 正大,田坂彰規,上田貴之,櫻井 薫
  • Organizer: 日本老年歯科医学会第25回学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-13 – 2014-06-14
• [Presentation] 粘度の異なる口腔保湿剤を用いた要介護高齢者の舌清掃後の微生物数および湿潤度の継時的変化 (2014)
  • Author(s): 田嶋さやか,竜 正大,大神浩一郎,上田貴之,櫻井 薫
  • Organizer: 粘度の異なる口腔保湿剤を用いた要介護高齢者の舌清掃後の微生物数および湿潤度の継時的変化
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-13 – 2014-06-14
• [Presentation] 食品の硬さの違いが自律神経活動に与える影響 (2014)
  • Author(s): 太田 緑, 上田貴之, 櫻井 薫
  • Organizer: 日本老年歯科医学会第25回学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-13 – 2014-06-14
• [Presentation] 口腔粘膜上皮における抗菌ペプチドディフェンシンの発現に影響を与える因子の検討 (2014)
  • Author(s): 大神浩一郎,竜 正大,内山 宙,古池崇志,戸村恭子,上田貴之,櫻井 薫
  • Organizer: 日本老年歯科医学会第25回学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-13 – 2014-06-14
• [Presentation] 簡単に調整が可能なインプラントオーバーデンチャーの維持力減退と角度許容性の検討 (2014)
  • Author(s): 山田裕介,古池崇志,高野智史,野田周太郎,吉井崇之,大神浩一郎,上田貴之,櫻井 薫
  • Organizer: 日本老年歯科医学会第25回学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-13 – 2014-06-14
• [Presentation] 義歯床下粘膜の血流変化と咀嚼リズムおよび反応性充血の関係 (2014)
  • Author(s): 荻野崇真,上田貴之,大神浩一郎,古池崇志,櫻井 薫
  • Organizer: 第297回東京歯科大学学会(例会)
  • Place of Presentation: 東京
  • Year and Date: 2014-06-07
• [Presentation] 総義歯口蓋部へのジルコニア応用の有益性 (2014)
  • Author(s): 和田 健,高野智史,田坂彰規,上田貴之,櫻井 薫
  • Organizer: 第297回東京歯科大学学会(例会)
  • Place of Presentation: 東京
  • Year and Date: 2014-06-07
• [Presentation] 抗酸化アミノ酸誘導体によるヒト気管支上皮細胞の細菌性炎症反応と粘液過剰産生の回避 (2014)
  • Author(s): 小泉ちあき,山田将博,上田貴之,石崎 憲,櫻井 薫
  • Organizer: 日本補綴歯科学会第123回学術大会
  • Place of Presentation: 仙台
  • Year and Date: 2014-05-24 – 2015-05-25
• [Presentation] 咀嚼能力および咬合状態の違いがチューイングによるストレス緩和効果に及ぼす影響 (2014)
  • Author(s): 菊地愛貴,田坂彰規,中西康輔,竹内 快,吉井崇之,上田貴之,櫻井 薫
  • Organizer: 日本補綴歯科学会第123回学術大会
  • Place of Presentation: 仙台
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] 咀嚼リズムの違いによる義歯床下粘膜の血流変化 (2014)
  • Author(s): 荻野崇真,上田貴之,大神浩一郎,古池崇志,櫻井 薫
  • Organizer: 日本補綴歯科学会第123回学術大会
  • Place of Presentation: 仙台
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] 総義歯口蓋部へのジルコニア応用の有益性－装着感と味覚への影響－ (2014)
  • Author(s): 和田 健,高野智史,田坂彰規,上田貴之,櫻井 薫
  • Organizer: 日本補綴歯科学会第123回学術大会
  • Place of Presentation: 仙台
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] Establishment of connective tissue integration with alkali-heat treated titanium surface (2014)
  • Author(s): Kato, E., Yamada, M. and Sakurai K.
  • Organizer: the 29th Annual Meeting of Academy of Osseointegration
  • Place of Presentation: Seattle, USA
• [Presentation] Cytofunctional preconditioning for auto-cell transplantation to enhance bone regeneration. (2014)
  • Author(s): Yamada, M., Ogawa, T. and Sakurai K.
  • Organizer: the 29th Annual Meeting of Academy of Osseointegration
  • Place of Presentation: Seattle, USA
• [Presentation] N-アセチル-L-システインの細胞内吸収によるヒト気管支上皮細胞の細菌性炎症反応の抑制 (2013)
  • Author(s): 小泉ちあき，山田将博，上田貴之，石崎 憲，玉井久貴，櫻井 薫
  • Organizer: 平成25年度(公社)日本補綴歯科学会東京支部学術大会
  • Place of Presentation: 東京
• [Presentation] Strong dermal collagen binding capability of alkali-heat-treated titanium surface with substantial nano-tuft-like structure (2013)
  • Author(s): Yamada M, Kato E, Sakurai K.
  • Organizer: International College of Prosthodontists 15th Biennial Meeting
  • Place of Presentation: Tronto, Italy
• [Presentation] アルカリ熱処理によるナノ毛羽立ち状チタン表面のヒト真皮コラーゲン付着強度の向上 (2013)
  • Author(s): 山田将博，加藤英治，櫻井 薫
  • Organizer: 日本口腔インプラント学会第43回学術大会
  • Place of Presentation: 福岡
• [Presentation] 義歯に付着した口腔内微生物に対する抗菌性機能水（バイオショット®）の除菌効果 (2013)
  • Author(s): 織田聖子,竜 正大,和泉佐知,上田貴之,山田将博,櫻井 薫
  • Organizer: 日本補綴歯科学会第122回学術大会
  • Place of Presentation: 福岡
• [Presentation] N-アセチル-L-システインの細胞内吸収によるヒト気管支上皮細胞の細菌性炎症反応の抑制 (2013)
  • Author(s): 小泉ちあき,山田将博,上田貴之,石崎 憲,玉井久貴,櫻井 薫
  • Organizer: 成25年度(社)日本補綴歯科学会東京支部総会
  • Place of Presentation: 東京
• [Presentation] A Development of the Most Suitable Titanium Topography for the Transmucosal Abutment Module and the Real Soft Tissue Integration (2013)
  • Author(s): Kato, E., Lember, J, R., Yamada, M., Sakurai, K.
  • Organizer: Academy of Osseoingration 28th Annual Meeting
  • Place of Presentation: Florida, USA
• [Presentation] Alkali-heat-treated Titanium Surface Enhances Collagen Deposition and Binding Strength (2013)
  • Author(s): Yamada, M., Kato, E., Sakurai, K.
  • Organizer: 91th General Session of the IADR
  • Place of Presentation: Seattle, USA
• [Presentation] Staphylococcal attachment reduces on UVC-irradiated titanium by changing surface properties (2012)
  • Author(s): Yamada, Y., Yamada, M., Ueda, T., Sakurai, K.
  • Organizer: 36th Annual Congress of the European Prosthodontic Association
  • Place of Presentation: Rotterdam, Netherlands
• [Presentation] UVC dose-dependent alteration in osteobiological and physicochemical properties of titanium (2012)
  • Author(s): Uchiyama, H., Yamada, M., Ishizaki, K., Sakurai, K.
  • Organizer: 36th Annual Congress of the European Prosthodontic Association
  • Place of Presentation: Rotterdam, Netherlands
• [Presentation] Antimicrobial Effect of Anti-bacterial Functional Water (Bioshot) on Streptococcus pneumoniae (2012)
  • Author(s): Kobayashi, K., Ryu, M., Ueda, T., Yamada.M ., Oda, S., Sakurai, K.
  • Organizer: 36th Annual Congress of the European Prosthodontic Association
  • Place of Presentation: Rotterdam, Netherlands
• [Book] 口腔科学 stomatology (2013)
  • Author(s): 櫻井 薫 (分担著)
  • Total Pages: 1096
  • Publisher: 朝倉書店
• [Remarks] 東京歯科大学老年歯科補綴学講座
  • URL: http://www.tdc.ac.jp/dept/rpg/
• [Remarks] 東京歯科大学有床義歯補綴学講座
  • URL: http://www.tdc.ac.jp/dept/rpg/