| Project/Area Number |
24592932
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
SAKURAI Kaoru 東京歯科大学, 歯学部, 教授 (20153950)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Masahiro 東北大学大学院歯学研究科分子, 再生歯科補綴学分野, 講師 (90549982)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | alloplast / bio-absorption / bone regeneration / bone substitute / socket preservation / ridge augmentation / 骨再生 / リン酸三カルシウム / 骨芽細胞 / コラーゲン |
|---|
| Outline of Final Research Achievements |
The objective of this study was to determine whether the beta-tricalcium phosphate (β-TCP)-collagen composite consisting of bovine dermis-derived soluble collagen sponge and porous β-TCP particles exerts excellent osteoconductive and biodegradation properties better than the existing inorganic/collagen composite for clinical use. Rat calvarial critical-sized bone defects implanted with the β-TCP-collagen composite covered with dense, continuous and mature bone tissue with nearly complete replacement of the graft material in contrast with limited amounts of immature trabecular bone and abundant remnant materials in the defects filled with the existing clinical composite material. The β-TCP-collagen composite exerted greater osteoconductivity and better biodegradation properties by enhancement of osteoblastic mineralization capability than the existing composite material.
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