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Study on bone matrix analysis for prognosis of tooth longevity to establish prosthetic treatment for individuals

Research Project

Project/Area Number 24592945
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthetic dentistry
Research InstitutionFukuoka Dental College

Principal Investigator

MATSUURA Takashi  福岡歯科大学, 歯学部, 准教授 (60330966)

Co-Investigator(Kenkyū-buntansha) SATO Hironobu  福岡歯科大学, 歯学部, 教授 (00145955)
TOKUTOMI Kentaro  福岡歯科大学, 歯学部, 助教 (20508981)
KATAFUCHI Michitsuna  福岡歯科大学, 歯学部, 助教 (90454933)
Research Collaborator YAMAUCHI Mitsuo  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords骨質 / 骨量 / 顎骨 / コラーゲン / 個人差 / 歯の寿命 / 下顎骨 / 翻訳後修飾 / 部位特異性 / 四肢骨 / 歯 / ミネラル / 骨基質
Outline of Final Research Achievements

We investigated what extent the individual variation was in mandibular bone quantity and a major bone matrix, collagen, and thier relation to tooth longevity. At the manidibular first molar region, cortical bone showed thicker in men than in women. Men did not exhibit the thickness decrease by age, while women did. Trabecular bone density did not differ by sex and age. A large extent of individual difference exists in the quantities of cortical and trabecular bones. In the mandibular mental region, the bone collagen content showed a large extent among individuals, though the extent of lysine hydroxylation of collagen did a relatively small variarion. The subjects showing larger content of collagen had almost two times as number of the remaining teeth as those showing smaller content of collagen. It is suggested that the mandibles have a large variation of collagen content among individuals and the variation could be a factor for tooth longevity.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] Characterization of the bone matrix and its contribution to tooth loss in human cadaveric mandibles2014

    • Author(s)
      Matsuura T, Sasaki M, Katafuchi M, Tokutomi K, Mizumachi E, Makino M, Naito T, Sato H
    • Journal Title

      Acta Odontologica Scandinavica

      Volume: 72 Issue: 8 Pages: 753-761

    • DOI

      10.3109/00016357.2014.903517

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Sex-related Differences in Cortical and Trabecular Bone Quantities at the Mandibular Molar2014

    • Author(s)
      Matsuura T, Mizumachi E, Katafuchi M, Tokutomi K, Kido H, Matsuura M, Sato H
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 23 Issue: 2 Pages: 267-274

    • DOI

      10.2485/jhtb.23.267

    • NAID

      130004480663

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distinct characteristics of mandibular bone collagen relative to long bone collagen: relevance to clinical dentistry2014

    • Author(s)
      Matsuura T, Tokutomi K, Sasaki M, Katafuchi M, Mizumachi E, Sato H
    • Journal Title

      BIOMED RESEARCH INTERNATIONAL

      Volume: 2014, Article ID 769414 Pages: 1-9

    • DOI

      10.1155/2014/769414

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] コラーゲン架橋形成2013

    • Author(s)
      松浦 尚志
    • Journal Title

      日本臨床 増刊号 最新の骨粗鬆症学

      Volume: 71巻増刊号2 Pages: 94-98

    • Related Report
      2012 Research-status Report
  • [Presentation] 硬軟組織の難治性疾患における病因解明と治療方法の開発に向けての取り組み2015

    • Author(s)
      黒嶋伸一郎,松浦尚志,熱田生,加来賢
    • Organizer
      日本補綴歯科学会
    • Place of Presentation
      大宮
    • Year and Date
      2015-05-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 下顎骨の主要骨基質成分の部位特異性-四肢骨との比較-2013

    • Author(s)
      松浦 尚志
    • Organizer
      公益社団法人日本口腔インプラント学会第30回九州支部学術大会
    • Place of Presentation
      別府
    • Related Report
      2012 Research-status Report
  • [Presentation] 骨コラーゲンが歯の寿命に寄与する可能性2012

    • Author(s)
      松浦 尚志
    • Organizer
      社団法人日本補綴歯科学会第121回学術大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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