Development of alveolar bone regenerative therapy using nano/microbubbles with IGF-I plasmid gene.
| Project/Area Number |
24592949
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
IIKUBO Masahiro 東北大学, 歯学研究科(研究院), 講師 (80302157)
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| Co-Investigator(Kenkyū-buntansha) |
SASANO Takashi 東北大学, 歯学研究科(大学院), 教授 (10125560)
KOJIMA Ikuho 東北大学, 歯学研究科(大学院), 助教 (80447169)
SAKAMOTO Maya 東北大学, 大学病院, 講師 (90157686)
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| Co-Investigator(Renkei-kenkyūsha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
MORI Shiro 東北大学, 大学病院, 講師 (80230069)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 再生歯学 / IGF-I / ＩＧＦ－Ｉ |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the longitudinal morphological changes in extraction sockets following sustained IGF-I treatment. Fourteen rats were subjected to right mandibular first molar extraction. Experimental rats received a continuous subcutaneous infusion of IGF-I. Micro-computed tomography scanning was performed immediately after tooth extraction, and at 1, 2, 3 and 6 weeks after extraction. New bone formation was markedly higher in the IGF-I treated group as compared with the control group. The loss in alveolar ridge height in the IGF-I group was significantly lower than that in the control group at each time point after extraction on the buccal side, and at 2, 3 and 6 weeks on the lingual side. In conclusions, IGF-I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction.
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Report
(4 results)
Research Products
(11 results)
