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Development of alveolar bone regenerative therapy using nano/microbubbles with IGF-I plasmid gene.

Research Project

Project/Area Number 24592949
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTohoku University

Principal Investigator

IIKUBO Masahiro  東北大学, 歯学研究科(研究院), 講師 (80302157)

Co-Investigator(Kenkyū-buntansha) SASANO Takashi  東北大学, 歯学研究科(大学院), 教授 (10125560)
KOJIMA Ikuho  東北大学, 歯学研究科(大学院), 助教 (80447169)
SAKAMOTO Maya  東北大学, 大学病院, 講師 (90157686)
Co-Investigator(Renkei-kenkyūsha) KODAMA Tetsuya  東北大学, 医工学研究科, 教授 (40271986)
MORI Shiro  東北大学, 大学病院, 講師 (80230069)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords再生歯学 / IGF-I / IGF-I
Outline of Final Research Achievements

The purpose of this study was to investigate the longitudinal morphological changes in extraction sockets following sustained IGF-I treatment. Fourteen rats were subjected to right mandibular first molar extraction. Experimental rats received a continuous subcutaneous infusion of IGF-I. Micro-computed tomography scanning was performed immediately after tooth extraction, and at 1, 2, 3 and 6 weeks after extraction. New bone formation was markedly higher in the IGF-I treated group as compared with the control group. The loss in alveolar ridge height in the IGF-I group was significantly lower than that in the control group at each time point after extraction on the buccal side, and at 2, 3 and 6 weeks on the lingual side. In conclusions, IGF-I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (6 results)

  • [Journal Article] Insulin-like growth factor I inhibits alveolar bone loss following tooth extraction in rats.2015

    • Author(s)
      Akira Kumasaka, Masahiro Iikubo, Takashi Nishioka, Ikuho Kojima, Noriaki Shoji, Maya Sakamoto, Takashi Sasano.
    • Journal Title

      Clin Implant Dent Relat Res.

      Volume: 印刷中 Issue: 6 Pages: 1174-1179

    • DOI

      10.1111/cid.12227

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] マウス咀嚼筋における筋疲労、浮腫性変化および痛みの関連に関する研究2014

    • Author(s)
      佐々城真、飯久保正弘、下里舞、佐藤しづ子、笹野高嗣
    • Journal Title

      歯科放射線

      Volume: 54 Pages: 1-6

    • NAID

      130004503224

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 歯根破折歯の画像の画像診断ガイドライン作成のためのプロジェクト研究2014

    • Author(s)
      佐野 司、飯久保正弘、有地榮一郎、岡野友宏、小林 馨、勝又明敏、笹野高嗣
    • Journal Title

      日本歯科医学会誌

      Volume: 33 Pages: 74-78

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic value of capsule-like rim enhancement on magnetic resonance imaging for distinguishing malignant from benign parotid tumours2014

    • Author(s)
      Sakamoto M, Iikubo M, Kojima I, Sasano T, Mugikura S, Murata T, Watanabe M, Shiga K, Ogawa T, Takahashi S
    • Journal Title

      Int J Oral Maxillofac Surg.

      Volume: 印刷中 Issue: 9 Pages: 1035-1041

    • DOI

      10.1016/j.ijom.2014.03.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of optimal length and insertion torque for miniscrews2013

    • Author(s)
      Makoto Suzuki, Toru Deguchi, Hisako Watanabe, Masahiro Seiryu, Masahiro Iikubo, Takashi Sasano, Koji Fujiyama, Teruko Takano-Yamamoto
    • Journal Title

      Am J Orthods Dentofacial Orthop

      Volume: 144 Issue: 2 Pages: 251-259

    • DOI

      10.1016/j.ajodo.2013.03.021

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] リンパ節転移治療におけるドキソルビシン封入温度感受性リポソームと光熱療法の併用2014

    • Author(s)
      松木大輔,大内友貴,阪本真弥,森士朗,小玉哲也.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] IGF-Iは抜歯後の歯槽骨吸収を抑制する2014

    • Author(s)
      熊坂 晃,飯久保 正弘,小嶋 郁穂,庄司 憲明,阪本 真弥,笹野 高嗣
    • Organizer
      第27回日本口腔診断学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 咬筋における筋疲労と浮腫性変化の関連に関する研究2013

    • Author(s)
      佐々城 真、飯久保正弘、下里 舞、笹野高嗣
    • Organizer
      第54回NPO法人日本歯科放射線学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] ラット抜歯窩治癒に及ぼすIGF-I投与の効果に関する研究2013

    • Author(s)
      熊坂 晃、飯久保正弘、小嶋郁穂、庄司憲明、阪本真弥、笹野高嗣
    • Organizer
      第54回NPO法人日本歯科放射線学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] インプラント術前CT画像による下顎骨断面形態の検討2013

    • Author(s)
      古内 壽、小嶋郁穂、酒井梓、金田直人、西岡貴志、菅原由美子、佐藤しづ子、飯久保正弘、庄司憲明、阪本真弥、笹野高嗣
    • Organizer
      第54回NPO法人日本歯科放射線学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] リンパ行性薬剤送達システムの開発2012

    • Author(s)
      畠山 友梨子, 李麗, サックスニコラ, 奥野竜希, 加藤茂樹, 阪本真弥, 森士朗, 小玉哲也.
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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