Mechanism of mechanoreceptive nerve regeneration: development of novel artificial dental roots with a mechanosensor
| Project/Area Number |
24592951
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dental engineering/Regenerative dentistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
Hayashi Haruhide 東北大学, 歯学研究科, 大学院非常勤講師 (90107293)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
千葉 美麗 東北大学, 歯学研究科, 講師 (10236820)
|
|---|
| Project Period (FY) |
2012-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 機械受容神経 / インプラント / メカニカルストレス / 歯根膜細胞 / 骨芽細胞 / 神経栄養因子 / メカノセンサー / 再生 / 歯周組織 / 人工歯根 / BMP-4 / 歯根膜 / 神経 / マイクロアレイ / 圧縮刺激 |
|---|
| Outline of Final Research Achievements |
Dental implant (artificial dental root) is a substitute for lost teeth and plays an important role in improving patient quality of life. This study aimed to elucidate the mechanism of mechanoreceptive nerve regeneration and to develop new dental implants with mechanosensors. Cell-specific expression of neurotrophic factors and neurotransmitters was elevated by mechanical stress loading on periodontal ligament cells and osteoblasts. Furthermore, gene expression pattern analysis suggested that several signal transduction pathways were involved in the process. These results have potential applications for the production of artificial dental roots that have mechanosensors similar to natural roots, have normal biting sensations, and exhibit physiological functions to suppress traumatic occlusal force.
|
Report
(6 results)
Research Products
(15 results)
-
-
-
-
-
-
[Presentation] Effects of Cyclic Tensile Strain on Mouse Stem Cells2017
Author(s)
Mayumi YASUDA, Mirei CHIBA, Shiho KATSUKI, Michiko MATSUOKA, Kaoru IGARASHI, Haruhide HAYASHI
Organizer
95th General Session & Exhibition of the IADR/46th AADR/41st CADR
Place of Presentation
Moscone West, San Francisco, CA 94103, USA.
Year and Date
2017-03-22
Related Report
Int'l Joint Research
-
[Presentation] A novel bisphosphonate, [4- (methylthio) phenylthio] methanebisphosphonate, facilitates bone formation by local administration to the alveolar bone in rats2017
Author(s)
Aiko Takizawa, Mirei Chiba, Yuka Narusawa, Makoto Nishimura, Takeru Ota, Mayumi Yasuda, Keiko Suzuki, Haruhide Hayashi, Kaoru Igarashi, Hisashi Shinoda
Organizer
The 2017 Japan-NIH joint Symposium
Place of Presentation
Seiryo Auditorium, Seiryo Campus , Tohoku University, Japan.
Year and Date
2017-02-15
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
