| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Dental implant (artificial dental root) is a substitute for lost teeth and plays an important role in improving patient quality of life. This study aimed to elucidate the mechanism of mechanoreceptive nerve regeneration and to develop new dental implants with mechanosensors. Cell-specific expression of neurotrophic factors and neurotransmitters was elevated by mechanical stress loading on periodontal ligament cells and osteoblasts. Furthermore, gene expression pattern analysis suggested that several signal transduction pathways were involved in the process. These results have potential applications for the production of artificial dental roots that have mechanosensors similar to natural roots, have normal biting sensations, and exhibit physiological functions to suppress traumatic occlusal force.
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