On demand regulation of tissue regenerative environment at the recipient site of transplantation therapy and dental implant
| Project/Area Number |
24592956
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dental engineering/Regenerative dentistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
NOZAKI Takenori 大阪大学, 歯学研究科(研究院), 助教 (30263304)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMADA Satoru 大阪大学, 大学院歯学部附属病院, 講師 (40359849)
YAMASHITA Motozo 大阪大学, 歯学部附属病院, 助教 (90524984)
KITAGAKI Jirota 大阪大学, 歯学部附属病院, 助教 (90570292)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 組織再生 / FGF-2 / インプラント / オステオインテグレーション / FGF－２ |
|---|
| Outline of Final Research Achievements |
The aim of this study is to provide good tissue regeneration to the recipient site of transplantation therapy and dental implant by on-demand regulation of regenerative environment. At the first, cleft model or severe horizontal bone defect model was prepared in beagle dogs. Grafting material made from high strength collagen was formed to fit to the bone defect. Subsequently, it was soaked to the solution containing FGF-2, and was placed into the defect. As the result, the grafting material provided good healing in cleft model, whereas it had fallen out from the defect due to the problem on strength in the horizontal defect model. Then, the dental implant was placed with/without FGF-2 application. As the result, it was revealed that FGF-2 promotes osteogenesis, and enhances the osseointegration even in the low primary stability condition. These results suggest that FGF-2 is a signaling molecule suitable for on-demand regulation to promote tissue regeneration.
|
Report
(4 results)
Research Products
(2 results)
-
[Presentation] 初期固定力の不十分なインプラントに対する FGF-2 の安定性獲得促進効果2014
Author(s)
野崎剛徳, 田中利江, 沢田啓吾, 小笹匡雄, 三木康史, 池上久仁子, 阪下裕美, 山本智美, 宮内静香, 北垣次郎太, 山下元三, 山田 聡, 白石紀子, 安齋 純
Organizer
第57回秋季日本歯周病学会学術大会
Place of Presentation
神戸国際展示場
Year and Date
2014-10-19
Related Report
-
