Establishment of Peri-implantitis treatment using injection of advanced platelet rich plasma/cells complex and photodynamic therapy.
| Project/Area Number |
24592961
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
MATSUYAMA TAKASHI 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (40253900)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO Takehiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (60419653)
MACHIGASHIRA Miho 鹿児島大学, 医学部・歯学部附属病院, 講師 (80253897)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | インプラント周囲炎 / 光殺菌法 / GDF-5 / 多血小板血漿 / 骨再生 / rhGDF-5 / 下顎骨膜由来細胞 / 骨芽細胞用細胞 / 骨形成能 / 脱感染 / 骨芽細胞 / オステオカルシン |
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| Outline of Final Research Achievements |
The purpose of the present study was to evaluate cell biocompatibility and decontamination effect using photodynamic therapy and GDF-5/platelet-rich plasma(PRP)/mandibular periosteal cells complex. Photodynamic therapy on contaminated titanium surfaces led to decontamination without alteration of characterization on them. GDF-5/PRP complex enhanced activity of alkaline phosphatase(ALP) in periosteal cells derived from rat mandibular compared to PRP alone stimulation. Furthermore, GDF-5/PRP complex induced the calcification of these cells on 14 days. These results suggest that GDF-5/PRP complex after photodynamic therapy on the contaminated titanium has an effect to induce bone regeneration.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.2015
Author(s)
Salunya Tancharoen, Takashi Matsuyama Koichi Kawahara, Miho Machigashira, Takashisa Arimura, Jan Plotempa, Yuko Nawa, Fumiyo Masuda, Miyacho Takahashi, Yoko Oyama, Chesta Binta, Teruo Hashiguchi, Ikuro Maruyama
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Journal Title
Related Report
Peer Reviewed / Open Access
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