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Antioxidant and osteogenic properties on a modified titanium implant

Research Project

Project/Area Number 24592966
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionShowa University

Principal Investigator

SHIBATA Yo  昭和大学, 歯学部, 助教 (30327936)

Co-Investigator(Kenkyū-buntansha) MIYAZAKI Takashi  昭和大学, 歯学部, 教授 (40175617)
MISHIMA Kenji  昭和大学, 歯学部, 教授 (50275343)
YAMADA Atsushi  昭和大学, 歯学部, 講師 (50407558)
YOSHIDA Misato  昭和大学, 歯学部, 兼任講師 (50555109)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsチタン / インプラント / 酸化ストレス / 細胞 / 陽極酸化処理 / 石灰化組織 / 創傷治癒
Outline of Final Research Achievements

Cells adhering onto implant surfaces are subjected to oxidative stress during wound healing processes. Although titanium and its alloys are among the most frequently used biomaterials in orthopedic and dental implants, titanium surfaces do not have antioxidant properties, and cells grown on these surfaces can show permanent oxidative stress. The present study assessed the antioxidant property and osteogenic properties of titanium samples with or without oxidation treatments. A thick rutile TiO2 film was observed on thermally oxidized titanium surfaces, while amorphous anatase TiO2 formed on anodically oxidized titanium surfaces prepared by discharging in 1 M Na2HPO4. A resistance to the depletion of reduced glutathione in adherent osteoblasts, which correlates with antioxidant behavior, occurred on anodically oxidized titanium. Enhanced osteogenic gene expressions and nano-biomechanical properties of mineralized tissue were achieved on anodically oxidized titanium.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2015 2014 2013 2012

All Journal Article (17 results) (of which Peer Reviewed: 17 results,  Open Access: 4 results,  Acknowledgement Compliant: 8 results) Presentation (6 results) (of which Invited: 4 results) Book (1 results)

  • [Journal Article] A review of improved fixation methods for dental implants. Part I: Surface optimization for rapid osseointegration2015

    • Author(s)
      Shibata Y., Tanimoto Y.
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 59 Issue: 1 Pages: 20-33

    • DOI

      10.1016/j.jpor.2014.11.007

    • NAID

      130007936698

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A review of improved fixation methods for dental implants. Part II: Biomechanical integrity at bone–implant interface2015

    • Author(s)
      Shibata Y., Tanimoto Y., Maruyama N., Nagakura M.
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 59 Issue: 2 Pages: 84-95

    • DOI

      10.1016/j.jpor.2015.01.003

    • NAID

      130007936685

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Surface topography, hardness, and frictional properties of GFRP for esthetic orthodontic wires2015

    • Author(s)
      Inami T., Tanimoto Y., Yamaguchi M., Shibata Y., Nishiyama N., Kasai K.
    • Journal Title

      Journal of Biomedical Materials Research Part B: Applied Biomaterials

      Volume: 103 Issue: 1 Pages: 88-95

    • DOI

      10.1002/jbm.b.33372

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhanced in vitro biological activities generated by surface characteristics of anodically oxidized titanium- the contribution of the oxidation effect2015

    • Author(s)
      Wurihan, Yamada A., Suzuki D., Shibata Y., Kamijo R, and Miyazaki T.
    • Journal Title

      European Cells and Materials

      Volume: 29

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Bone micro-fragility caused by the mimetic aging processes in α-klotho deficient mice: in situ nanoindentation assessment of dilatational bands2015

    • Author(s)
      Maruyama N., Shibata Y., Mochizuki A., Yamada A., Maki K., Inoue T., Kamijo R., Miyazaki T.
    • Journal Title

      Biomaterials

      Volume: 47 Pages: 62-71

    • DOI

      10.1016/j.biomaterials.2015.01.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In-situ quasi-static and dynamic nanoindentation tests on calcified nodules formed by osteoblasts: Implication of glucocorticoids responsible for osteoblast calcification2015

    • Author(s)
      Miyamoto S., Miyamoto Y., Shibata Y., Yoshimura K., Izumida E., Suzuki H., Miyazaki T., Maki K., Kamijo R.
    • Journal Title

      Acta Biomaterialia

      Volume: 12 Pages: 216-226

    • DOI

      10.1016/j.actbio.2014.10.038

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Strain-rate stiffening of cortical bone: observations and implications from nanoindentation experiments2014

    • Author(s)
      Maruyama N., Shibata Y., Wurihan, Swain M., Kataoka Y., Takiguchi Y., Yamada A., Maki K. and Miyazaki T.
    • Journal Title

      Nanoscale

      Volume: 6 Issue: 24 Pages: 14863-14871

    • DOI

      10.1039/c4nr03180f

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nanoindentation tests to assess polymerization of resin-based luting cement2014

    • Author(s)
      Sato M., Fujishima A., Shibata Y., Miyazaki T.
    • Journal Title

      Dental Materials

      Volume: 30 Issue: 9 Pages: 1021-1028

    • DOI

      10.1016/j.dental.2014.05.034

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nanomechanical properties and molecular structures of in vitro mineralized tissues on anodically oxidized titanium surfaces.2014

    • Author(s)
      Jang, I-. K., Tanaka, R., Wurihan, Suzuki, D., Shibata Y., Fujisawa, N., Tanimoto, Y., Ogura, K., Kamijo, R., Miyazaki, T.
    • Journal Title

      Nanomedicine

      Volume: 10 Issue: 3 Pages: 629-637

    • DOI

      10.1016/j.nano.2013.09.007

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lysyl oxidase like-2 reinforces unsatisfactory ossification induced by bone morphogenetic protein-2: relating nanomechanical properties and molecular changes.2013

    • Author(s)
      Shibata, Y., Suzuki, D., Wurihan, Yamada, A., Maruyama, N., Fujisawa, N., Kamijo, R., Miyazaki, T.
    • Journal Title

      Nanomedicine

      Volume: 9 Issue: 7 Pages: 1036-1047

    • DOI

      10.1016/j.nano.2013.04.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Morphology and In Vitro Behavior of Electrospun Fibrous Poly(D,L-lactic acid) for Biomedical Applications.2013

    • Author(s)
      Inami T., Tanimoto Y., Ueda M., Shibata Y., Hirayama S., Yamaguchi M., and Kasai K.
    • Journal Title

      Advances in Materials Science and Engineering

      Volume: 140643 Pages: 1-6

    • DOI

      10.1155/2013/140643

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro demineralization of tooth enamel subjected to two whitening regimes.2013

    • Author(s)
      Ogura K., Tanaka R., Shibata Y., Miyazaki T., Hisamitsu H.
    • Journal Title

      Journal of the American Dental Association

      Volume: 144 Issue: 7 Pages: 799-807

    • DOI

      10.14219/jada.archive.2013.0190

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new modified laser pretreatment for porcelain zirconia bonding2013

    • Author(s)
      Liu Dan
    • Journal Title

      Dental Materials

      Volume: 29 Issue: 5 Pages: 559-565

    • DOI

      10.1016/j.dental.2013.03.002

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lysyl oxidase like-2 reinforces unsatisfactory ossification induced by bone morphogenetic protein-2: relating nanomechanical properties and molecular changes.2013

    • Author(s)
      Shibata Y.
    • Journal Title

      Nanomedicine: Nanotechnology, Biology, Medicine

      Volume: 9

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro demineralization of tooth enamel subjected to two whitening regimes.2013

    • Author(s)
      Ogura K.
    • Journal Title

      Journal of the American Dental Association

      Volume: 144

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antioxidant and osteogenic properties of anodically oxidized titanium2012

    • Author(s)
      Iwai-Yoshida M., Shibata Y., Wurihan, Suzuki D., Fujisawa N., Tanimoto Y., Kamijo R., Maki K. and Miyazaki T.
    • Journal Title

      Journal of the Mechanical Behavior of Biomedical Materials

      Volume: (in press) Pages: 230-236

    • DOI

      10.1016/j.jmbbm.2012.01.016

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tape-cast and sintered beta-tricalcium phosphate laminates for biomedical applications: Effect of milled A1203 fiber additives on microstructural and2012

    • Author(s)
      Tanimoto Y,
    • Journal Title

      Journal of Biomedical Materials Research Part B: Applied Biomaterials

      Volume: 100 Issue: 8 Pages: 2261-2268

    • DOI

      10.1002/jbm.b.32796

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Age-related degradation of mouse cortical bone:implications for alfa-klotho gene responsible for bone mechanical integrity in a series of nanoindentation experiments2014

    • Author(s)
      Maruyama N., Shibata Y., Mochizuki A., Miyazaki T., Inoue T., Maki K.
    • Organizer
      APCFS/SIF-2014
    • Place of Presentation
      オーストラリア シドニー
    • Year and Date
      2014-12-09 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nanoindentation tests to assess polymerization quality of resin-based luting cement2014

    • Author(s)
      柴田 陽
    • Organizer
      The 3rd trilateral dental symposium on advance in zirconia and its use as a dental materials
    • Place of Presentation
      東京
    • Year and Date
      2014-06-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Nanomechanical Testing Technology for In Vitro Mineralized Tissue.2013

    • Author(s)
      Shibata Y., Suzuki D., Wurihan., Yamada A., Maruyama N., Kamijo R., Miyazaki T.
    • Organizer
      2nd Meeting of the International Association for Dental Research- Asia Pacific Region
    • Place of Presentation
      タイ バンコク
    • Related Report
      2013 Research-status Report
  • [Presentation] Nanomechanical testing technology for engineered tissues2013

    • Author(s)
      Yo Shibata
    • Organizer
      THE 2ndTRILATERAL DENTAL SYMPOSIUM on “DENTAL VIRTUAL EDUCATION TODAY”
    • Place of Presentation
      日本歯科大学
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Nano mechanical testing technology for in vitro mineralized tissue on titanium2012

    • Author(s)
      Wurihan
    • Organizer
      The 1st Trilateral “Zirconia & Titanium Today” Dental Materials Science Symposium
    • Place of Presentation
      香港
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Contact osteogenesis of titanium implants stimulated by wire-type electric discharge machining and an irradiation of ultraviolet lamp2012

    • Author(s)
      Kataoka Y.
    • Organizer
      The 1st Trilateral “Zirconia & Titanium Today” Dental Materials Science Symposium
    • Place of Presentation
      香港
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] The New Frontiers in Research for Oral Cancer2013

    • Author(s)
      Yo Shibata, Takashi Miyazaki
    • Total Pages
      209
    • Publisher
      MARUZEN PLANET
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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