Novel noninvasive diagnostic and therapeutic strategy for diffuse sclerosing osteomyelitis of mandible

• Project/Area Number: 24592977
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: YAMAZAKI YUTAKA 北海道大学, 歯学研究科(研究院), 教授 (90250464)
• Co-Investigator(Kenkyū-buntansha): KITAGAWA Yoshimasa 北海道大学, 大学院歯学研究科, 教授 (00224957) ; HATA Hironobu 北海道大学, 大学院歯学研究科, 助教 (70450830)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 骨髄炎 / びまん性硬化性下顎骨骨髄炎 / 骨シンチ / ビスフォスフォネート製剤 / FDG-PET

Outline of Final Research Achievements

Diffuse sclerosing osteomyelitis (DSO) of the mandible has been considered an intractable disease of unknown etiology and no curative tretment. At present, most effective treatment of DSO is to perform diagnosis as soon as possible, and to administer bisphosphonates without conventional therapy. The purpose of this study was to appraise the value of FDG-PET/CT and 3-phase bone scinigraphy in differentiation of DSO from othere osteomyelitis of jaws. DSO has unique characteristics of lower FDG uptake and higher pool and static images. These results suggest that FDG-PT combined with 3-phase bone scintigraphy could be clinically useful for the differentiation of DSO from other osteomyelitis of jaws.

Research Products

• [Journal Article] 顎骨疾患における核医学応用の可能性 (2013)
  • Author(s): 北川善政、秦 浩信
  • Journal Title: PET journal Volume: 22 Pages: 10-12
  • NAID: 40019753838
• [Presentation] FDG-PETを用いたビスフォスフォネート関連顎骨壊死に対する高圧酸素療法の有効性の評価 (2014)
  • Author(s): 浅香卓也、秦 浩信、宮腰昌明、佐藤 明、佐藤 淳、北川善政
  • Organizer: 日本口腔外科学会総会学術大会
  • Place of Presentation: 幕張メッセ国際会議場(千葉県・千葉市）
  • Year and Date: 2014-10-17
• [Presentation] FDG-PET and 3-phase bone scintigraphy to differentiate diffuse sclerosing osteomyelitis from other refractory chronic osteomyelitis of jaws (2013)
  • Author(s): Kitagawa Y, Asaka T, Hata H, Sato J, Yamazaki Y, Okamoto S, Hattori N, Shiga T, Tamaki N
  • Organizer: 2013' Society of Nuclear medicine
  • Place of Presentation: Vancouver Convention Center (Canada)
• [Presentation] Role of FDG-PET in evaluating different 4 types of chronic osteomyelitis of jaws in combination with 3-phase bone scintigraphy (2012)
  • Author(s): Kitagawa Y, Kyan-Onodera, Yamazaki Y, Hata H, et al
  • Organizer: 2012' Society of Nuclear Medicine
  • Place of Presentation: Miami Beach Convention center (USA)