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Detection of oral cancer stem cell which indicates epithelial to mesenchymal transition and development of new cancer treatment that targeted oral cancer stem cell

Research Project

Project/Area Number 24592979
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionAkita University

Principal Investigator

NAKATA AKIRA  秋田大学, 医学部, 助教 (50400510)

Co-Investigator(Kenkyū-buntansha) FUKUDA Masayuki  秋田大学, 医学部, 准教授 (20272049)
SUGUYAMA Toshihiro  秋田大学, 医学部, 定年退職 (00127242)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords口腔癌幹細胞 / Snail / 上皮間葉形質転換 / 浸潤 / 転移 / 免疫抑制 / 口腔癌 / 癌幹細胞
Outline of Final Research Achievements

In this study, we try to detect oral cancer stem cell and clear that a part of cancer cell which gain invasion ability, express "Snail" molecule, indicates epithelial to mesenchymal transition and changes into the favorable character of invasion and metastasis.
First, cDNA of human Snail was included in expression vector for culture cell of mammals and gene was introduced into tongue cancer cell line (HSC4). when Snail molecule was introduced into HSC4 cells that was cobblestone-shaped form, which changes into the spindle-shaped form, and atttached weakly between cell to cell.Next, cultured HSC4 and HSC4/Snail cells were transplanted under the back of nude mice. For 3 months of transplantation and the size of the formed tumor were estimated. Tumorogenesis similar to human squamous cell carcinoma which is the history of HSC4 was seen, and Snail participated in promotion of tumorogenesis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (9 results)

  • [Journal Article] 下顎歯肉に発生した腺扁平上皮癌の1例2014

    • Author(s)
      中田 憲
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 60(4) Pages: 193-198

    • NAID

      130005072005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下顎歯肉に発生した腺扁平上皮癌の1例2014

    • Author(s)
      中田 憲
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 60 Pages: 193-198

    • NAID

      130005072005

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 80歳以上の高齢者口腔癌に対する逆行性選択的動注化学放射線療法の臨床的検討2013

    • Author(s)
      中田 憲
    • Journal Title

      みちのく齒學會雑誌

      Volume: 44 Pages: 72-73

    • Related Report
      2013 Research-status Report
  • [Journal Article] 口腔癌に対する皮下埋め込み式リザーバーを用いた逆行性超選択的動注化学療法の経験2012

    • Author(s)
      本間高志,中田 憲,福田雅幸
    • Journal Title

      頭頸部癌

      Volume: 38(1) Pages: 21-25

    • NAID

      10030815719

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 舌痛症に対する加工ブシ末製剤(アコニンサン錠TM)の効果に関する検討2012

    • Author(s)
      谷藤未典,高野裕史,濱田知穂,山崎雅人,桑島精一,中田 憲,福田雅幸
    • Journal Title

      みちのく歯学会雑誌

      Volume: 42・43巻合併1・2号 Pages: 58-59

    • Related Report
      2012 Research-status Report
  • [Journal Article] 病院歯科口腔外科における口腔ケアの医療連携について2012

    • Author(s)
      濱田知穂,高野裕史,谷藤未典,山崎雅人,桑島精一,中田 憲,福田雅幸
    • Journal Title

      みちのく歯学会雑誌

      Volume: 42・43巻合併1・2号 Pages: 76-77

    • Related Report
      2012 Research-status Report
  • [Presentation] 口腔癌への放射線治療に伴う口腔乾燥症に対するピロカルピン塩酸塩の治療効果に関する臨床的検討2015

    • Author(s)
      中田 憲
    • Organizer
      日本有病者歯科医療学会
    • Place of Presentation
      旭川
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口腔癌幹細胞を標的とした新規癌治療開発に関する基礎的研究2014

    • Author(s)
      中田 憲
    • Organizer
      日本口腔外科学会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 当科で経験した原発性骨内扁平上皮癌7例に関する臨床的検討2014

    • Author(s)
      中田 憲
    • Organizer
      日本頭頸部癌学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨頭付き再建用チタンプレートを用いた下顎骨再建術後の形態,機能および術後合併症に関する臨床的検討

    • Author(s)
      中田 憲
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 下顎骨放射線性骨髄炎術後に増殖性の石灰化像が観察された1例

    • Author(s)
      中田 憲
    • Organizer
      第58回(公社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 80歳以上の高齢者口腔癌に対する選択的動注化学療法の臨床的検討

    • Author(s)
      中田 憲
    • Organizer
      第66回東北地区歯科医学会
    • Place of Presentation
      秋田
    • Related Report
      2013 Research-status Report
  • [Presentation] 下顎骨半側切除後に骨頭付き再建用チタンプレートを用いて下顎骨再建を行った症例の臨床的検討

    • Author(s)
      中田 憲,桑島精一,山崎雅人,高野裕史,福田雅幸
    • Organizer
      第66回 NPO法人 日本口腔科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Presentation] EPA配合栄養機能食品プロシュアを併用しTPF療法8クール完遂した再発舌癌の1例

    • Author(s)
      中田 憲,高野裕史,福田雅幸
    • Organizer
      第36回 日本頭頸部癌学会
    • Place of Presentation
      島根
    • Related Report
      2012 Research-status Report
  • [Presentation] 骨頭付き再建用チタンプレートを用いた下顎骨再建術後の形態,機能および術後合併症に関する臨床的検討

    • Author(s)
      中田 憲,桑島精一,大渕真彦,山崎雅人,高野裕史,福田雅幸
    • Organizer
      第37回 日本頭頸部癌学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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