An in vitro study on the role of calcium in bisphosphonate-related osteonecrosis of jaw.
| Project/Area Number |
24592983
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Mie University (2013-2014)
University of Toyama (2012) |
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Principal Investigator |
ARAI Naoya 三重大学, 医学(系)研究科(研究院), 教授 (80323723)
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| Co-Investigator(Kenkyū-buntansha) |
TOMIHARA Kei 富山大学, 大学院医学薬学研究部, 助教 (70404738)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ビスフォスフォネート / カルシウム / 細胞毒性 / 相乗作用 / 上皮細胞 |
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| Outline of Final Research Achievements |
Bisphosphonate (BP) is known to possess cytotoxicity in mucosal tissues. In this study, we demonstrated that calcium enhances the cytotoxic effects of BP on cultured epithelial cells, using one of the popular intravenous BPs, zoledronate (ZA). It is of note that low concentrations of ZA, which alone had little effects, could be toxic to the epithelial cells depending on the conditions of extracellular calcium. We think that the present results will be an important knowledge to elucidate the cytotoxic mechanism of BP to mucosal tissues.
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Report
(4 results)
Research Products
(3 results)
