| Project/Area Number |
24592984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyoto University |
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Principal Investigator |
FUJIMURA Kazuma 京都大学, 医学(系)研究科(研究院), 非常勤講師 (30252399)
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| Co-Investigator(Kenkyū-buntansha) |
SONOBE Junya 京都大学, 医学研究科, 講師 (50464219)
BESSHO Kazuhisa 京都大学, 医学研究科, 教授 (90229138)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 生体材料 / 粘膜保護材 / 粘膜修復 / 再生医学 |
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| Outline of Final Research Achievements |
In the treated group (n=8), a tendency for the epithelium in a mucosal defect with a diameter of 5 mm to extend towards the center from the peripheral mucosa was observed. Approximately 2 weeks thereafter, the epithelial formation area was 12.56mm2 on average, and the scar contraction rate was approximately 36%. In the non-treated group (n=7), the epithelial formation area was on average 7.46 mm2, and the scar contraction rate was approximately 62%. With LYDEX, mucosal proliferation was faster, and mucosal defect sites were covered more quickly compared to those in the non-treated group; therefore, this suggested that this reduces the scar contraction rate. FGF-2 was added to LYDEX in a similar experimental method (n=4). Two weeks following treatment, the epithelial formation area was 15.11mm2 on average, and the scar contraction rate was 23%.
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