| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Oral cancer tissues generally show the invasion mass histopathologically. Various sized the invasion mass consists of canver cells which maintains cell-cell adhesion and progresses their growth into the submucosa. In this study, we invastigated the mechanism that invasion mass forms with EMT-dependent invasion system and non-EMT dependent EMT system via humoral factor. Humoral factors, CCN1(Cyr61) and galectin-1 which we newly found contributeed the interaction between EMT phenotype tumor cells and non-EMT phenotype tumor cells for the forming tumor invasion mass. This mechanism gives a new insight for the understanding of the local invasion of tumor and could come in useful for the blockage of tumor progression.
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