| Project/Area Number |
24592995
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Ryuji 鹿児島大学, 医学部・歯学部附属病院, 准教授 (50398278)
NAKAMURA Norifumi 鹿児島大学, 医歯(薬)学総合研究科, 教授 (60217875)
HIJIOKA Hiroshi 鹿児島大学, 医学部・歯学部附属病院, 講師 (70305150)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 低酸素環境 / 口腔癌 / 代謝 / メタボローム解析 / 解糖系代謝 / メタボローム / EMT / 口腔癌細胞 |
|---|
| Outline of Final Research Achievements |
We analyzed metabolomics of oral squamous cell carcinoma using HSC-2,HSC-4 cell lines cultivated under normoxia and hypoxia condition. In particular, glycolysis, amino sugars and pentose phosphate pathway were accelerated for both cell lines, but, under hypoxia condition, pentose phosphate pathway was accelerated. We found that hypoxia condition increased the motility and invasiveness of HSC-2, HSC-4 cells and that induced malignant transformation. These findings suggest that metabolic changes under hypoxia environment influence acquisition of malignancy.
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