The study of identification of causative metals with PIXE method by directly analyzing trace elements in the oral lichen planus-affected mucous
| Project/Area Number |
24593002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Sera Kouitirou 岩手医科大学, 医学部, 教授 (00230855)
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| Co-Investigator(Renkei-kenkyūsha) |
Iijima Shin 岩手医科大学, 歯学部, 助教 (60376754)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔扁平苔癬 / PIXE法 / 微量元素分析 / 金属アレルギー / 口腔扁平苔癬様病変 / OLP / OLL / 歯学 / 臨床 / 元素分析 / 加速器 / 分析化学 / 人間生活環境 |
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| Outline of Final Research Achievements |
The purpose of our research is to identify causative metals of oral lichen planus by PIXE method. Subjects were 72 patients with oral lichen planus (pOLP group), and 12 patients with oral lichenoid lesion (OLL group) chosen from pOLP group. The control is elemental data of 100 healthy persons (control group).
As to appearance ratio of elements in oral mucosa, levels of Au and Y were significantly higher in pOLP group than in control group. The contaminating elements in oral mucosa of pOLP group had a lower appearance ratio than the control but each of the contaminating elements was more abundant. Tendencies were seen for contaminating elements to be more abundant in saliva than in serum and for essential elements to be more abundant in serum than in saliva. In OLL group, as to appearance ratio of elements in oral mucosa, the levels of Au were significantly higher and as to the concentration of elements, Al and Ti were more abundant than in control group.
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Report
(5 results)
Research Products
(25 results)
