Analysis of molecular mechanism of caldecrin on osteoclastic bone resorption by inflammatory cytokine
| Project/Area Number |
24593004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOMOMURA Akito 明海大学, 歯学部, 教授 (60188810)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | カルデクリン / 炎症性骨吸収 |
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| Outline of Final Research Achievements |
We collected primary cells derived from murine bone marrow. LPS promoted osteoclastic differentiation of primary bone marrow cells after priming activation with RANKL. Caldecrin inhibited this priming step. It suggests that Caldecrin will be valuable theraputic agent for inflammatory diseases associated with bone resorption.
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Report
(4 results)
Research Products
(29 results)
