Elucidation of recurrence / metastasis related gene using mapping array of oral cancer
Project/Area Number |
24593009
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Kanagawa Dental College (2014) Tokyo Dental College (2012-2013) |
Principal Investigator |
YAMAMOTO Nobuharu 神奈川歯科大学, 歯学研究科(研究院), 准教授 (60385185)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 口腔がん / DNAマッピングアレイ / ヘテロ接合性消失(LOH) / 口腔癌 / 癌抑制遺伝子 / ヘテロ接合性消失 |
Outline of Final Research Achievements |
Molecular biological search and identification of cancer have a variety of clinical significance. Microarray, proteomics and metabolome analyses are powerful analytical methods for rapid screening of tumor markers. As the results, it was revealed that a number of genes are specifically expressed in oral cancers. As the results of CAN and LOH analyses of the entire genome, three candidate gene loci (D1S1189, D1S2151, D1S2595) were identified on 1q31.1 region.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] A case of lower gingival carcinoma with drug-induced interstitial pneumonia caused after chemotherapy with peplomycin2015
Author(s)
Yamamoto N., Fuse Y., Yoshida Y., Suzuki T., Noguchi S., Katakura A., Tanaka Y., Shibahara T., Takano N.
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 27
Pages: 92-95
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinicopathological study of tumor depth in tongue squamous cell carcinoma2014
Author(s)
Yamamoto N., Osaka R., Ogane S., Sugahara K., Yamamoto M., Muramatsu K., Watanabe A., Narita M., Yakushiji T., Nomura T., Yamauchi T., Takano N., Shibahara T., Saito T., Yoshida K., Sato K., Katakura A., Matsuzaka K.
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 26
Pages: 118-121
Related Report
Peer Reviewed / Open Access
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[Journal Article] A case of lower gingival carcinoma with drug-induced interstitial pneumonia caused after chemotherapy with peplomycin.2014
Author(s)
Yamamoto N., Fuse Y., Yoshida Y., Suzuki T., Noguchi S., Katakura A., Tanaka Y., Shibahara T., Takano N.
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Clinicopathological study of tumor depth in tongue squamous cell carcinoma.2013
Author(s)
Yamamoto N., Osaka R., Ogane S., Sugahara K., Yamamoto M., Muramatsu K., Watanabe A., Narita M., Yakushiji T., Nomura T., Yamauchi T., Takano N., Shibahara T., Saito T., Yoshida K., Sato K., Katakura A., Matsuzaka K.
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Aneurysmal bone cyst in mandible: Report of 2 cases and review of literature.2013
Author(s)
Sakuma T., Yamamoto N., Onda T., Sugahara K., Yamamoto M., Muramatsu K., Watanabe A., Kamio T., Sakamoto J., Sano T., Matsuzaka K., Takano N., Shibahara T.
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 25
Pages: 129-133
Related Report
Peer Reviewed
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[Journal Article] Bisphosphonate-related osteonecrosis of jaw (BRONJ) in Japanese population: A case series of 13 patients at our clinic.2013
Author(s)
Nomura T., Shibahara T., Uchiyama T., Yamamoto N., Shibui T., Yakushiji T., Watanabe A., Muramatsu K., Ogane S., Murayama M., Sekine R., Nakata E., Fujimoto Y.
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Journal Title
The Bulletin Tokyo Dental College
Volume: 54
Pages: 117-125
NAID
Related Report
Peer Reviewed
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[Journal Article] A 5-year activity report in the Oral Cancer Center, Tokyo Dental College.2013
Author(s)
Yamamoto N., Sato K., Yamauchi T., Suzuki T., Osaka R., Kin M., Yoshida Y., Noguchi S., Ishizaki K., Takano M., Katakura A., Shibahara T., Takano N.
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Journal Title
The Bulletin Tokyo Dental College
Volume: 54
NAID
Related Report
Peer Reviewed
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[Journal Article] Clinical study of multiple primary and double cancers including oral squamous cell carcinoma.2012
Author(s)
Yamamoto N, Okubo T, Sakuma T, Sugahara K, Yamamoto M, Muramatsu K, Watanabe A, Yakushiji T, Nomura T, Takano N, Shibahara T.
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 24
Pages: 189-194
Related Report
Peer Reviewed
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[Presentation] Clinical application of full-scale-model made by 3-dimensional ink jet printer for orthognathic surgery2014
Author(s)
Katsumi, Y., Sugahara, K., Hamada, Y., Yamamoto, N., Fujiwara, W., Tojo, K., Takano, M., Shibahara, T., Matsunaga, S., Yoshinari, M.
Organizer
5th Triennial International ADT Congress
Place of Presentation
北京(中国)
Year and Date
2014-09-07
Related Report
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[Presentation] Usefulness of 3DHD movie for surgical practices and medical education in OMFS2014
Author(s)
Sugahara, K., Takano, M., Kasahara, K., Yamamoto, N., Saito, C., Shibahara, T.
Organizer
5th Triennial International ADT Congress
Place of Presentation
北京(中国)
Year and Date
2014-09-07
Related Report
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[Presentation] Molecular epidemiological study of oral cancer in Tokyo Dental College2014
Author(s)
Yamamoto, N., Sugahara, K., Onda, T., Nomura, T., Takano, M., Shibahara, T.
Organizer
第11回アジア口腔顎顔面外科学会
Place of Presentation
西安(中国)
Year and Date
2014-08-23
Related Report
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[Presentation] Detection of surgical margin using fluorescence visualization as a useful tool for oral squamous cell carcinoma2014
Author(s)
Nomura, T., Morikawa, T., Bessho, H., Yamamoto, N., Takano, N., Shibahara, T.
Organizer
第11回アジア口腔顎顔面外科学会
Place of Presentation
西安(中国)
Year and Date
2014-08-23
Related Report
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[Presentation] Oral cancer mass examinations provided by Tokyo Dental College cooporating with dental associations2014
Author(s)
Ohta, R., Yamamoto, N., Motrikawa, T., Bessho, H., Nomura, T., Shibahara, T.
Organizer
2014年台湾口腔顎顔面外科学会総会
Place of Presentation
台南市(台湾)
Related Report
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[Presentation] Detection of surgical margin using fluorescence visualization as a useful for oral squamous cell carcinoma2014
Author(s)
Nomura, T., Motrikawa, T., Bessho, H., Yamamoto, N., Takano, N., Shibahara, T.
Organizer
2014年台湾口腔顎顔面外科学会総会
Place of Presentation
台南市(台湾)
Related Report
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