| Project/Area Number |
24593010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Research Collaborator |
石川 玄 ヒューマン・マタボローム・テクノロジーズ(株), 研究員
MASAHIRO SUGIMOTO 慶應義塾大学, 先端生命科学研究所, 教授
David TW Wong University of California, School of Dentistry, Associate Dean of Research
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 唾液 / メタボローム解析 / 口腔癌 / バイオマーカー / タンパク |
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| Outline of Final Research Achievements |
The purpose of this study was to characterize metabolic systems in oral squamous cell carcinoma (OSCC) using Capillary Electrophoresis / Mass Spectrometry (CE-MS) metabolome analysis of saliva. Saliva were obtained from patients with OSCC patients (n=22) and from healthy controls (n=21), who visited the Department of Dentistry, Oral and Maxillofacial Surgery, Tokyo Dental Collage Ichikawa General Hospital. We applied metabolome comprehensive and quantitative analysis in the saliva from 22 OSCC patients and 21 healthy controls using CE-MS. Furthermore, focused Choline, Urea, BACC cycle, and 3-Hydroxybutyric acid. Some groups reported Choline, BACC cycle in OSCC using metabolome analysis. These findings suggest the usefulness of metabolites as a salivary biomarker for OSCC.
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