Preventive effect of melatonin against radiation-induced mucosal injury
| Project/Area Number |
24593015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATOMURA Kazuhito 鶴見大学, 歯学部, 教授 (80243715)
HONDA Masaki 日本大学, 歯学部, 准教授 (70361623)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | メラトニン / 放射線障害 / 口腔粘膜 / 口腔粘膜障害 / 放射線治療 / 唾液腺障害 |
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| Outline of Final Research Achievements |
Melatonin is secreted by the pineal gland primarily during the night. Its secretion is controlled by the light:dark cycle. Melatonin is also produced and secreted in various extrapineal organs, and we reported in salivary gland, too. Melatonin has a variety of physiological actions, particularly, free-radical scavenging and antioxydation. In this study, to elucidate the possibility of preventive effect of melatonin against radiation-induced mucosal injury, we examined the affect of melatonin on damaged tissues of oral mucosa of radiated mice. As a result, melatonin prevent the damages of oral tissues. From these facts, we have explored the possibility that melatonin have preventive effect aginst radiation-induced mucosal injury.
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Report
(4 results)
Research Products
(4 results)
