| Project/Area Number |
24593016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
KATAOKA Shiki 鶴見大学, 歯学部, 臨床助手 (80624676)
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| Co-Investigator(Kenkyū-buntansha) |
SATOMURA Kazuhito 鶴見大学, 歯学部, 教授 (80243715)
TATEHARA Seiko 鶴見大学, 歯学部, 講師 (90380089)
TOKUYAMA Reiko 鶴見大学, 歯学部, 助教 (20380090)
IDE Shinji 鶴見大学, 歯学部, 学部助手 (00611998)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | レプチン / 口腔粘膜 / 創傷治癒 / 口腔粘膜創傷治癒 / 創傷治療薬 |
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| Outline of Final Research Achievements |
Leptin, a circulating anti-obesity hormone, exhibits many physiological properties. Recently, leptin was isolated from saliva. In this study, we investigated the physiological role of leptin in the oral cavity by focusing on its effect on wound healing in the oral mucosa. As a result, topical administrarion of leptin significantly promoted wound healing and shortened the duration required for complete healing. Histological analysis of gingival tissue beneath the ulceration showed a denser distribution of blood vessels in the leptin-traeted group. Also, migration of human oral epithelial cells was accelerated in the presence of leptin. From these facts, topically administration leptin was shown to promote wound healing on the oral mucosa by accelerating epithelial cell migration and enhancing angiogenesis around the wounded area. These results strongly suggest that topical administration of leptin may be useful as a treatment to promote wound healing in the oral mucosa.
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