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The study of oral cancer screening by photo imaging

Research Project

Project/Area Number 24593019
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

YOSHIDA Kenji  愛知学院大学, 歯学部, 教授 (40183701)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Hayao  愛知県がんセンター(研究所), 腫瘍病理学, 研究員 (20207830)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords口腔がん / 近赤外(NIR) 蛍光イメージング / VELscope® / スクリーニング / ICG標識抗ヒトpodoplanin抗体 / 口腔がんの早期診断 / 光イメージング / 口腔癌 / 可視化 / 早期診断 / 蛍光イメージング
Outline of Final Research Achievements

Oral squamous cell carcinoma is not infrequently overlooked by conventional examination. Recently, light-induced tissue autofluorescence examination has been introduced. Upon illumination by blue light (436 nm), specific components of fluorophores present in the mucosa including flavin adenine dinucleotide and nicotinamide adenine dinucleotide of the cross-linked collagen/elastin fibers emit low-energy light, which is visualized as the autofluorescence image of the mucosa. Malignant transformation is usually associated with increase in the epithelial cell density, which reduces the excitation of collagen fiber, leading to a decrease in the blue-green autofluorescence and darker appearance compared to uninvolved mucosa. This autofluorescence visual imaging such as VELscope® is a widely used. The aim of this study is to investigate about fluorescence imaging method that can assist and improve sensitive and specific detection and monitoring of OSCC.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014 Other

All Presentation (2 results) (of which Invited: 2 results)

  • [Presentation] Photodynamic therapy and diagnosis2014

    • Author(s)
      Kenji Yoshida
    • Organizer
      14th world congress for Laser Dentistry
    • Place of Presentation
      パリ(フランス)
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Photodynamic diagnosis and therapy in oral cancer

    • Author(s)
      Kenji Yoshida
    • Organizer
      14th Congress of World Federation for Laser Dentistry
    • Place of Presentation
      Paris
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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