Development of the treatment that targeted an arachidonate cascade of the oral cancer neighborhood environment
Project/Area Number |
24593022
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OGA Noritaka 北海道大学, 歯学研究科, 助教 (40548202)
樋田 京子 北海道大学, 歯学研究科(研究院), その他 (40399952)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 腫瘍血管内皮 / アラキドン酸カスケード / 腫瘍血管内皮細胞 / COX-2 / プロスタサイクリン / プロスタサイクリンレセプター / アラキドン酸 / 癌 |
Outline of Final Research Achievements |
We found that COX-2/ prostaglandin E2 (PGE2) and prostacyclin (PGI2) was expressed highly in a tumor endothelial cells.In others to use expensive molecular target medicine for as a treatment strategy of the vascularization inhibition therapy, the COX-2/ prostaglandin E2 (PGE2) inhibitor could used cancer treatment.Targeting tumor angiogenesis is an established strategy for cancer therapy.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Identification of Novel Targets for Antiangiogenic Therapy by Comparing the Gene Expressions of Tumor and Normal Endothelial Cells2014
Author(s)
Otsubo T., et al., Hida Y., Ohga N., Sato H., Kai T., Matsuki Y., Takasu H., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Nonomura K., Hida K.
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Journal Title
Cancer Sci.
Volume: (印刷中)
Issue: 5
Pages: 560-567
DOI
Related Report
Peer Reviewed / Open Access
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