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Development of the treatment that targeted an arachidonate cascade of the oral cancer neighborhood environment

Research Project

Project/Area Number 24593022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionHokkaido University

Principal Investigator

KOBORI YOSHINORI  北海道大学, 大学病院, 助教 (70374551)

Co-Investigator(Kenkyū-buntansha) OGA Noritaka  北海道大学, 歯学研究科, 助教 (40548202)
樋田 京子  北海道大学, 歯学研究科(研究院), その他 (40399952)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords腫瘍血管内皮 / アラキドン酸カスケード / 腫瘍血管内皮細胞 / COX-2 / プロスタサイクリン / プロスタサイクリンレセプター / アラキドン酸 / 癌
Outline of Final Research Achievements

We found that COX-2/ prostaglandin E2 (PGE2) and prostacyclin (PGI2) was expressed highly in a tumor endothelial cells.In others to use expensive molecular target medicine for as a treatment strategy of the vascularization inhibition therapy, the COX-2/ prostaglandin E2 (PGE2) inhibitor could used cancer treatment.Targeting tumor angiogenesis is an established strategy for cancer therapy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) Remarks (2 results)

  • [Journal Article] Identification of Novel Targets for Antiangiogenic Therapy by Comparing the Gene Expressions of Tumor and Normal Endothelial Cells2014

    • Author(s)
      Otsubo T., et al., Hida Y., Ohga N., Sato H., Kai T., Matsuki Y., Takasu H., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Nonomura K., Hida K.
    • Journal Title

      Cancer Sci.

      Volume: (印刷中) Issue: 5 Pages: 560-567

    • DOI

      10.1111/cas.12394

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 下顎枝矢状分割術における下顎頭の水平的変化と顎関節症状の関係について2014

    • Author(s)
      小堀善則
    • Organizer
      第59回 日本口腔外科学会総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Remarks] 北海道大学大学院 歯学研究科 血管生物学教室

    • URL

      http://www.den.hokudai.ac.jp/vascular-biology/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 北海道大学大学院 歯学研究科 血管生物学教室

    • URL

      http://www.den.hokudai.ac.jp/vascular-biology/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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