Molecular targeting therapy by targeting mTOR pathway combined with radiation therapy for oral cancer

• Project/Area Number: 24593025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nagasaki University
• Principal Investigator: TOBITA Takayoshi 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (00336174)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 口腔癌 / 分子標的治療薬 / mTOR / 口腔癌細胞 / 増殖抑制

Outline of Final Research Achievements

Although mTOR inhibitors are expected to be options for the treatment of cancers, it is little known about the treatment effects of mTOR inhibitos when combined with radiation therapy. Therefore, we assessed the potential of this combined therapy in vitro. As a result, cell proliferation of three cancer cell lines [Hela cell, cisplatin-resistant cell (RCB1152), and lung squamous carcinoma cell (RCB0444)] was strongly inhibited after irradiation when exposed to mTOR inhibitors in culture.

Research Products

• [Journal Article] Spontaneous eruption of involved second molar in unicystic ameloblastoma of the mandible after marsupialization followed by enucleation: a case report. (2012)
  • Author(s): Sano K, Yoshimura H, Tobita T, Kimura S, Imamura Y.
  • Journal Title: J Oral Maxillofac Surg. Volume: 71 Issue: 1 Pages: 66-71
  • DOI: 10.1016/j.joms.2012.04.014
  • Peer Reviewed
• [Journal Article] Gustatory sweating in the submandibular region following neck dissection: a case with thermographic evaluation and review of the literature. (2012)
  • Author(s): Yoshimura H, Tobita T, Kumakiri M, Sano K.
  • Journal Title: J Oral Maxillofac Surg. Volume: 70 Issue: 11 Pages: 667-673
  • DOI: 10.1016/j.joms.2012.06.179
  • Peer Reviewed
• [Journal Article] Applicability of buccal fat pad grafting for oral reconstruction. (2012)
  • Author(s): Toshihiro Y, Nariai Y, Takamura Y, Yoshimura H, Tobita T, Yoshino A, Tatsumi H, Tsunematsu K, Ohba S, Kondo S, Yanai C, Ishibashi H, Sekine J.
  • Journal Title: Int J Oral Maxillofac Surg. Volume: 42 Issue: 5 Pages: 640-610
  • DOI: 10.1016/j.ijom.2012.07.009
  • Peer Reviewed
• [Journal Article] Metachronous manifestation of carcinoma ex pleomorphic adenoma in a buccal minor salivary gland and the contralateral parotid gland: a case report and review of the literature. (2012)
  • Author(s): Sano K, Fujita S, Sekine J, Uehara M, Sakihama N, Hayashi T, Yoshimura H, Tobita T.
  • Journal Title: J Oral Maxillofac Surg. Volume: 70 Issue: 11 Pages: 2701-2712
  • DOI: 10.1016/j.joms.2011.12.016