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Development of a novel functional preservation therapy against advanced, recurrent or unresectable oral cancers.

Research Project

Project/Area Number 24593034
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionYamaguchi University

Principal Investigator

HARADA Koji  山口大学, 医学(系)研究科(研究院), 助教 (60253217)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords人工癌幹細胞 / リプログラミング因子 / エピソーマルベクター / 口腔癌 / 癌幹細胞 / リプログラミング / 口腔癌細胞 / 脱分化 / 動注化学放射線療法 / IGRT
Outline of Final Research Achievements

It is often difficult to treat advanced, recurrent or unresectable oral cancers. A new strategy must be needed. In these years, the cancer stem cells (CSCs) are an important target for the development of novel strategies in above oral cancer treatment. However, CSCs-targeted new anti-cancer drug discovery is currently hindered by the lack of easy and reliable methods for collecting sufficient number of CSCs. Briefly,artificially-manufactured cancer stem cells are essential. In this project,we could generate the transfectant cells ( HSC2/hOCT3/4-shp53-F+hSK+hUL) with CSCs properties by introduction of defined reprogramming factors (Oct3/4, sh53, Sox2, Klf4, l-Myc and Lin28) into HSC2 tongue cancer cells. Our findings suggest that artificial cancer stem cells developed by cellular reprogramming may be useful for investigating the acquisition of potential malignancy as well as screening the CSCs-targeting drugs.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (9 results) (of which Invited: 1 results)

  • [Journal Article] Osteogenic cell fractions isolated from mouse tongue muscle2015

    • Author(s)
      Harada K, Harada T, Ferdous T, Takenawa T. and Ueyama Y.
    • Journal Title

      Mol. Med. Rep.

      Volume: - Issue: 1 Pages: 31-36

    • DOI

      10.3892/mmr.2015.3350

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Paclitaxel in combination with cetuximab exerts antitumor effect by suppressing NF-κB activity in human oral squamous cell carcinoma cell lines2014

    • Author(s)
      Harada K, Kobayashi H, Ferdous T, Ueyama Y.
    • Journal Title

      International Journal of Oncology

      Volume: 45 Issue: 6 Pages: 2439-2445

    • DOI

      10.3892/ijo.2014.2655

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Establishment of 5-fluorouracil-resistant oral squamous cell carcinoma cell lines with epithelial-to-mesenchymal transition changes2014

    • Author(s)
      KOJI HARADA, TARANNUM FERDOUS and YOSHIYA UEYAMA
    • Journal Title

      INTERNATIONAL JOURNAL OF ONCOLOGY

      Volume: 44 Issue: 4 Pages: 1302-1308

    • DOI

      10.3892/ijo.2014.2270

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 口腔扁平上皮癌における分子標的薬CetuximabのTS-1増強効果についての基礎的研究2013

    • Author(s)
      原田耕志、原田豊子、上山吉哉
    • Journal Title

      頭頸部癌

      Volume: 39 Pages: 317-324

    • NAID

      130004510171

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of schedule dependent metronomic S-1 chemotherapy in human oral squamous cell carcinoma cells2013

    • Author(s)
      TARANNUM FERDOUS, KOJI HARADA, TAKANORI KIN, TOYOKO HARADA and YOSHIYA UEYAMA
    • Journal Title

      INTERNATIONAL JOURNAL OF ONCOLOGY

      Volume: 43 Issue: 1 Pages: 271-279

    • DOI

      10.3892/ijo.2013.1950

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of schedule dependant metronomic S-1 chemotherapy in human oral squamous cell carcinoma cells2013

    • Author(s)
      Ferdous T, Harada K, Kin T, Harada T, Ueyama Y
    • Journal Title

      International Journal of Oncology

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] リプログラミング因子導入による癌細胞の脱分化2014

    • Author(s)
      原田 耕志、Ferdous T、上山 吉哉
    • Organizer
      日本口腔科学会 中国・四国地方部会
    • Place of Presentation
      徳島大学歯学部 大講義室 (徳島)
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Establishment of Induced Cancer Stem Cells by Transfection of a Tongue Cancer Cell Line with Yamanaka‘s Factor2014

    • Author(s)
      Harada K, Ferdous T, Harada T, Ueyama Y.
    • Organizer
      EACMFS 2014
    • Place of Presentation
      Praque Congress Centre, Praque, Czech Republic
    • Year and Date
      2014-09-23 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Basic research on combined effect of Cetuximab and Paclitaxel on oral squamous cell carcinomas2014

    • Author(s)
      Takenawa T, Harada K, Kobayashi H, Harada T, Ferdous T, Ueyama Y.
    • Organizer
      EACMFS 2014
    • Place of Presentation
      Praque Congress Centre, Praque, Czech Republic
    • Year and Date
      2014-09-23 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口腔白板症の癌化における転写因子STAT3を介したM2マクロファージの関与2013

    • Author(s)
      原田耕志、内田堅一郎、真野隆充、上山吉哉
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      東京 (京王プラザホテル)
    • Related Report
      2013 Research-status Report
  • [Presentation] 口腔白板症の癌化におけるNF-κBを介したM2マクロファージの関与2013

    • Author(s)
      原田 耕志、Tarannum Ferdous、白石 瑠里子、久野 高博、岡本 正人、上山吉哉
    • Organizer
      第17回日本がん免疫学会
    • Place of Presentation
      宇部 (ANAクラウンプラザホテル宇部)
    • Related Report
      2013 Research-status Report
  • [Presentation] Establishment of 5-fluorouracil-resistant oral squamous cell carcinoma cell lines and their cancer stem cell like characteristics2013

    • Author(s)
      Koji Harada, Tarannum Ferdous and Yoshiya Ueyama
    • Organizer
      ICOMS 2013
    • Place of Presentation
      BARCELONA SPAIN
    • Related Report
      2013 Research-status Report
  • [Presentation] 口腔癌に対するフッ化ピリミジン系経口抗癌剤を用いた新たな治療戦略2012

    • Author(s)
      原田耕志
    • Organizer
      第66回日本口腔科学会総会
    • Place of Presentation
      広島国際会議場 (広島)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 口腔扁平上皮癌における分子標的薬CetuximabのTS-1増強効果2012

    • Author(s)
      原田耕志、原田豊子、上山吉哉
    • Organizer
      第36回日本頭頸部癌学会
    • Place of Presentation
      島根県民会館 (松江)
    • Related Report
      2012 Research-status Report
  • [Presentation] Antitumor effect of S-1 in combination with Cetuximab on human oral squqmous cell carcinoma cell lines in vitro and in vivo2012

    • Author(s)
      Harada K, Harada T, Ueyama Y.
    • Organizer
      ACOMS 2012
    • Place of Presentation
      Discovery Kartika Plaza Hotel Bali, Indonesia
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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