| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In order to improve the outcome from oral cancer treatments, we have to pay constant attention to the occult metastases. We focused that the almost cancer cells showed the resistance to apoptosis, and aimed to release these resistance. In this study, we have used oral squamous cell carcinoma cell lines with and without distinct metastatic ability, and revealed the relationship between their apoptosis sensitivity and the metastatic ability. SAS cells which have no metastatic potency showed modest sensitivity to TRAIL, whereas SAS-T5 cells and SAS-L1 cells, a clone with high metastatic potential showed robust resistance. We found that the mechanisms underlying the differences in these resistance to TRAIL was an activity of Src kinase and the basal levels of A20 expression.
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