| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
miRNAs closely related to the factors influencing the development and the progression of oral squamous cell carcinoma such as epithelial-mesenchymal transition, food ingredients and oxidative stress were extracted. In miR-29b, miR-494 and miR-21 extracted, the target genes of them were identified and the mechanism of their actions was analyzed. Although the mechanism was not clarified enough to report in the period of research, the on-going experiments using culture cells and animal models are expected to lead to the novel strategy in future by targeting these miRNAs and in combination with chemotherapy and radiotherapy.
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