| Project/Area Number |
24593039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Seiji 昭和大学, 歯学部, 准教授 (10432634)
MUKUDAI Yoshiki 昭和大学, 歯学部, 助教 (50325099)
YOSHIBA Sayaka 昭和大学, 歯学部, 助教 (60555358)
新谷 悟 昭和大学, 歯学部, 教授 (80294429)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔癌 / miRNA / microarray analysis / 転移予測マーカー / 転移 / 転移予測因子 |
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| Outline of Final Research Achievements |
In this study, we regarded miRNA as a metastasis prediction factor of oral cancer and cyclopaedically analyze was done in normal oral mucosa, oral cancer and metastasis tissues. As a result of microarray analysis, the expression of twelve miRNAs were increased and eleven miRNAs were decrease.While only non-significant differential expression of these miRNAs between oral cancer tissue and metastatic tissue was recognized, a tendency differential expression was recognizd.
Oral cancer cells proliferation were accelerated by These miRNAs introduce into the cells but the cells metastatic potential were not accelerated.
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