| Project/Area Number |
24593045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MATSUI KEIKO 東北大学, 歯学研究科(研究院), 助教 (00302159)
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| Co-Investigator(Kenkyū-buntansha) |
KAMAKURA Shinji 東北大学, 大学院医工学研究科, 教授 (80224640)
TAKAHASHI Tetsu 東北大学, 大学院歯学研究科, 教授 (60226850)
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| Research Collaborator |
KAWAI Tadashi 東北大学病院, 助教 (50547263)
EZOE Yushi 東北大学病院, 医員
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リン酸カルシウム系生体材料 / リン酸オクタカルシウム（OCP) / OCP/Collagen 複合体 / ビーグル犬 / 人工的骨欠損 / 骨再生 / 止血作用 / 抜歯窩 / OCP/Collagen複合体 / リン酸オクタカルシウム(OCP) / OCP/Col |
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| Outline of Final Research Achievements |
The octacalcium phosphate collagen composites (OCP/Col) of a bone regeneration material were applied to tooth extraction sockets. We examined how to use OCP/Col as a hemostatic material, and the regenerative bone was investigated with regard to maintenance of the alveolar ridge after healing of extraction sockets. After canine mandibular premolars were extracted, OCP/Col disks were implanted into the sockets. One side was completely closed with a mucoperiosteal flap, while the other was left as an open wound. Three months later, equivalent healing was observed on both sides. However, the buccolingual width of the open wound tended to be larger. Intraoral findings were not remarkable.
Therefore, OCP/Col can be used in extraction sockets as a hemostatic material, and the regenerative bone effectively maintains the alveolar ridge. OCP/Col may thus be applicable to socket preservation.
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