Acid sensitive ion channel in postoperative pain

• Project/Area Number: 24593047
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tohoku University
• Principal Investigator: KIDO Kanta 東北大学, 大学病院, 助教 (40343032)
• Co-Investigator(Kenkyū-buntansha): MASAKI Eiji 東北大学, 大学院歯学研究科, 教授 (40221577) ; OHTANT Norimasa 東北大学, 大学院歯学研究科, 非常勤講師 (60338879)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 術後痛 / 酸感受性イオンチャネル / PAR-2 / 肥満細胞

Outline of Final Research Achievements

We are focusing on the mechanism underlying postoperative pain status. In this study, we examined whether pH changes in wound effect on the sensitization of primary afferents and increase post operative pain using rat behavioral testing and in vitro muscle-nerve preparation. We demonstrated that acid sensitive ion channel is one of the most important factors of postoperative pain in deep tissue.

Research Products

• [Journal Article] The Effect of Deep Tissue Incision on pH Responses of Afferent Fibers and Dorsal Root Ganglia Innervating Muscle (2013)
  • Author(s): Kanta Kido, M Gautam, CJ. Benson, He Gu, T J. Brennan
  • Journal Title: Anesthesiology Volume: 119 Issue: 5 Pages: 1186-1197
  • DOI: 10.1097/aln.0b013e31829bd791
  • Peer Reviewed
• [Journal Article] Mast cell stabilization promotes antinociceptive effects in a mouse model of postoperative pain. (2013)
  • Author(s): Yasuda M
  • Journal Title: J Pain Res Volume: 6 Pages: 161-166
  • DOI: 10.2147/jpr.s41527
  • Peer Reviewed
• [Presentation] Nociceptive sensitization by activation of Protease-Activated Receptor 2 (PAR-2) in rats (2014)
  • Author(s): Kanta Kido, Eiji Masaki
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington D.C. USA
  • Year and Date: 2014-11-18
• [Presentation] ラット術後痛モデルにおけるProteinase-activated receptor 2 (PAR-2) 活性化の影響 (2014)
  • Author(s): 城戸幹太、安田真、正木英二
  • Organizer: 第42回日本歯科麻酔学会
  • Place of Presentation: 新潟市
  • Year and Date: 2014-10-11
• [Presentation] Nociceptive sensitization by activated Proreinase-Activated Receptor 2 (2013)
  • Author(s): Kanta Kido, Eiji Masaki
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
• [Presentation] Proteinase-activated receptor 2 活性化による侵害受容感作 (2013)
  • Author(s): 城戸幹太 安田真 正木英二
  • Organizer: 第41回日本歯科麻酔学会
  • Place of Presentation: 横浜