| Project/Area Number |
24593049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Gunma University |
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Principal Investigator |
Yokoo Satoshi 群馬大学, 医学(系)研究科(研究院), 教授 (00322206)
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| Co-Investigator(Kenkyū-buntansha) |
Takayama Yu 群馬大学, 医学部附属病院, 助教 (60507490)
小川 将 群馬大学, 医学部附属病院, 助教 (70622041)
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| Co-Investigator(Renkei-kenkyūsha) |
OGAWA Masaru 群馬大学, 医学部附属病院, 助教 (70622041)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | keratinocyte (上皮細胞） / 創傷治癒 / 人工口腔粘膜 / Smad / TGF-β / 神経系再生 / 口腔粘膜 / 瘢痕 / keratinocyte / cytokine / TGF-β/Smad シグナル |
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| Outline of Final Research Achievements |
We succeeded in fabricating an ex vivo produced oral mucosa equivalent (EVPOME) consisted of patients’ oral keratinocytes and an acellular dermal matrix, entirely without heterogenic animal proteins or xenotransplantation, and have reported its usefulness. To clarify the superiority of EVPOME with keratinocytes over the artificial dermis without keratinocytes (Terdermis®:Terumo, Tokyo) in wound healing, we evaluated the following items in this study: 1) clinical factors; 2) regeneration of the neuromucosal system; 3) epithelial defense system associated with the nervous system with keratinocyte-derived cytokines.
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