Pain have a correlation with Depression~Relevance of NPY~

Research Project

Project/Area Number	24593052
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Surgical dentistry
Research Institution	Niigata University
Principal Investigator	Tsurumaki Tatsuru 新潟大学, 医歯学系, 助教 (10345522)
Co-Investigator(Kenkyū-buntansha)	YOSHIKAWA Hiroyuki 新潟大学, 医歯学総合病院, 医員 (20547575) SEO Kenji 新潟大学, 医歯学系, 教授 (40242440)
Project Period (FY)	2012-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	神経ペプチド / 末梢神経障害
Outline of Final Research Achievements	I developed a trigeminal neuropathic pain model in which the withdrawal threshold to mechanical stimulation of whisker pad was significantly decreased after inferior alveolar nerve injury. Therefore, I performed experiments to examine neuropeptide Y and its receptors (Y1, Y2, Y4 and Y5) expression using this neuropathic pain model. Expression of neuropeptide Y mRNA was significantly increased after inferior alveolar nerve injury. The expressions of neuropeptide Y receptors were also changed after inferior alveolar nerve injury.

Report

(5 results)