Pain have a correlation with Depression~Relevance of NPY~
| Project/Area Number |
24593052
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Hiroyuki 新潟大学, 医歯学総合病院, 医員 (20547575)
SEO Kenji 新潟大学, 医歯学系, 教授 (40242440)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 神経ペプチド / 末梢神経障害 |
|---|
| Outline of Final Research Achievements |
I developed a trigeminal neuropathic pain model in which the withdrawal threshold to mechanical stimulation of whisker pad was significantly decreased after inferior alveolar nerve injury. Therefore, I performed experiments to examine neuropeptide Y and its receptors (Y1, Y2, Y4 and Y5) expression using this neuropathic pain model. Expression of neuropeptide Y mRNA was significantly increased after inferior alveolar nerve injury. The expressions of neuropeptide Y receptors were also changed after inferior alveolar nerve injury.
|
Report
(5 results)
Research Products
(3 results)
