The development of stealth-typed midazolam-encapsulating nano drug carrier for oral administration

Research Project

Project/Area Number	24593055
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Surgical dentistry
Research Institution	Okayama University
Principal Investigator	MIYAWAKI Takuya 岡山大学, 医歯(薬)学総合研究科, 教授 (00219825)
Co-Investigator(Renkei-kenkyūsha)	YASUDA Tatsuji 岡山大学, 名誉教授 (30092357)
Research Collaborator	TOMOYASU Yumiko MORI Megumi
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	歯学 / 薬理学
Outline of Final Research Achievements	We developed a drug carrier for oral administration of intravenous drugs. We produced the pegylated and miniaturized midazolam-encapsulating liposome as a stealth-typed nano drug carrier in order to improve the bioavailability of midazolam. We orally gave them to rabbits and confirmed the effect of the pegylated and miniaturized midazolam-encapsulating liposomes on the bioavailability of midazolam. The results showed that the pegylated and miniaturized midazolam-encapsulating liposomes increased the bioavailability of midazolam orally administrated.

Report

(4 results)