Studies on the mechanisms of noradrenaline and dopamine release in the nucleus accumbens

• Project/Area Number: 24593062
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nihon University
• Principal Investigator: TAKADA Koji 日本大学, 歯学部, 講師 (00216657)
• Co-Investigator(Kenkyū-buntansha): SAIGUSA Tadashi 日本大学, 歯学部, 教授 (50277456)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 口腔ジスキネジア / ノルアドレナリン / ドパミン / アドレナリン受容体 / ラット / アセチルコリン / 側坐核

Outline of Final Research Achievements

Oral dyskinesia is a neurological disorder is characterized by involuntary repetitive orofacial movement. It is associated with aging or use of drugs for Parkinson’s disease and antipsychotics. The detailed biological basis of the syndrome is unclear, but the pharmaco-behavioural studies indicate that enhance of dopamine function in the nucleus accumbens and striatum plays major role for the induction of repetitive jaw movements of rats. In the present study, we investigated the roles of adrenaline receptor subtypes in the regulation of accumbal dopaminergic activity in freely moving rats, using the in vivo brain microdialysis technique.

Research Products

• [Journal Article] Simultaneous activation of α1A-, α1B- and α1D-adrenoceptor subtypes in the nucleus accumbens reduces accumbal dopamine efflux in freely moving rats (2015)
  • Author(s): Yuri Aono, Hiroko Taguchi, Tadashi Saigusa, Takuya Uchida, Koji Takada, Hatakazu Takiguchi, Tetsuo Shirakawa, Noriyoshi Shimizu, Noriaki Koshikawa and Alexander R. Cools
  • Journal Title: Behavioural Pharmacology Volume: 26 Issue: 1 and 2 - Special Issue Pages: 73-80
  • DOI: 10.1097/fbp.0000000000000113
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Synergistic, but not separate, stimulation of accumbal β1- and β2-adrenoceptors alters the accumbal dopamine efflux in freely moving rats (2013)
  • Author(s): Aono Y., Saigusa T., Taguchi H., Uchida T., Takada K., Koshikawa N. and Cools A.R.
  • Journal Title: European Journal of Pharmacology Volume: 715 Issue: 1-3 Pages: 363-369
  • DOI: 10.1016/j.ejphar.2013.04.035
  • Peer Reviewed
• [Journal Article] Concomitant activation of α1-receptor subtypes in the nucleus accumbens reduces accumbal dopamine efflux in freely moving rats (2013)
  • Author(s): Aono Y. et al.
  • Journal Title: Journal of Pharmacological Sciences Volume: 121, suppl 1 Pages: 214-214
  • Peer Reviewed
• [Presentation] Intra-accumbal administration of endomorphin-2 decreases acetylcholine efflux via mu receptors and increases dopamine efflux independent of mu receptors in the nucleus accumbens of freely moving rats (2014)
  • Author(s): Yuri Aono, Hiroko Taguchi, Yuri Kiguchi, Takuya Uchida, Koji Takada, Noriaki Koshikawa and Tadashi Saigusa
  • Organizer: 29th The International College of Neuropsychopharmacology (CINP)
  • Place of Presentation: Vancouver (Canada)
  • Year and Date: 2014-06-23
• [Presentation] ラットの側坐核へのエンドモルフィン-2の局所投与が示す同部位のアセチルコリン放出抑制作用 (2014)
  • Author(s): 青野悠里，田口寛子，木口友里，高田耕司，前田隆秀，越川憲明，三枝 禎
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台国際センター（宮城県）
• [Presentation] ラットの側坐核のドパミン放出抑制におけるα1受容体サブタイプの関与
  • Author(s): 青野悠里ほか
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡県福岡市福岡国際会議場