| Project/Area Number |
24593071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
MATSUNO MINO 北海道大学, 歯学研究科(研究院), 専門研究員 (80374544)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUIRI Takashi 北海道大学, 大学院歯学研究科, 助教 (10322819)
YOSHIMURA Yoshitaka 北海道大学, 大学院歯学研究科, 准教授 (30230816)
DEYAMA Yoshiaki 北海道大学, 大学院歯学研究科, 准教授 (80271667)
IIDA Junichiro 北海道大学, 大学院歯学研究科, 教授 (90151232)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 再生医療 / 間葉系幹細胞 / 造血幹細胞 / 歯学 / 幹細胞 / 口唇裂・口蓋裂 / 再生医学 / 骨移植 |
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| Outline of Final Research Achievements |
The alveolar bone grafting of the cleft lip and palate patients has been carried out by using autologous bone. However, stem cell therapy would be widely available in the regeneration of craniofacial bone defects. The purpose of this study is to examine that the possibility of the regeneration of alveolar bone tissue by using bone marrow-derived mesenchymal stem cell (BMMSC) and hematopoietic stem cell (HSC). Transplantation of both BMMSC and HSC approaches has a favorable effect on regeneration of new bone. As the result, it is considered that the using of both BMMSC and HSC is effective method for the bone regeneration.
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