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Development of the alveolar bone tissue by using bone marrow-derived mesenchymal stem cell and hematopoietic stem cell

Research Project

Project/Area Number 24593071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionHokkaido University

Principal Investigator

MATSUNO MINO  北海道大学, 歯学研究科(研究院), 専門研究員 (80374544)

Co-Investigator(Kenkyū-buntansha) KIKUIRI Takashi  北海道大学, 大学院歯学研究科, 助教 (10322819)
YOSHIMURA Yoshitaka  北海道大学, 大学院歯学研究科, 准教授 (30230816)
DEYAMA Yoshiaki  北海道大学, 大学院歯学研究科, 准教授 (80271667)
IIDA Junichiro  北海道大学, 大学院歯学研究科, 教授 (90151232)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords再生医療 / 間葉系幹細胞 / 造血幹細胞 / 歯学 / 幹細胞 / 口唇裂・口蓋裂 / 再生医学 / 骨移植
Outline of Final Research Achievements

The alveolar bone grafting of the cleft lip and palate patients has been carried out by using autologous bone. However, stem cell therapy would be widely available in the regeneration of craniofacial bone defects. The purpose of this study is to examine that the possibility of the regeneration of alveolar bone tissue by using bone marrow-derived mesenchymal stem cell (BMMSC) and hematopoietic stem cell (HSC). Transplantation of both BMMSC and HSC approaches has a favorable effect on regeneration of new bone. As the result, it is considered that the using of both BMMSC and HSC is effective method for the bone regeneration.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Regenerating bone tissue using a combination of bone marrow mesenchymal stem cells and hematopoietic stem cells2014

    • Author(s)
      Mino Matsuno, Takashi Kikuiri, Yoshitaka Yoshimura, Yoshiaki Deyama, Kuniaki Suzuki, Junichiro Iida
    • Journal Title

      Wound Repair and Regeneration

      Volume: 22

    • Related Report
      2013 Research-status Report
  • [Journal Article] Short-term mechanical stress inhibits osteoclastogenesis via suppression of DC-STAMP in RAW264.7 cells2013

    • Author(s)
      Sumika Kameyama, Yoshitaka Yoshimura,Takeshi Kameyama, Takashi Kikuiri, Mino Matsuno, Yoshiaki Deyama, Kuniaki Suzuki,Junichiro Iida
    • Journal Title

      International Journal of Molecular Medicine

      Volume: 31巻 Issue: 2 Pages: 292-298

    • DOI

      10.3892/ijmm.2012.1220

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 間葉系幹細胞と造血系幹細胞の併用による骨組織再生療法の試み

    • Author(s)
      松野美乃
    • Organizer
      日本創傷治癒学会
    • Place of Presentation
      かでる2・7(札幌市)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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