| Project/Area Number |
24593073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MONMA Yuko 東北大学, 加齢医学研究所, 非常勤講師 (00191073)
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| Co-Investigator(Kenkyū-buntansha) |
OGASAWARA Koetsu 東北大学, 加齢医学研究所, 教授 (30323603)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 感染症 / ウイルス感染 / 歯の形成異常 / 炎症 / 自然免疫 / 細胞傷害性 / 細胞障害性 |
|---|
| Outline of Final Research Achievements |
On epidemiological studies, it has been reported that the hypoplasia of the teeth is affected by the virus infection. In this study, we investigated that the effect on the formation of a tooth by viral infection in view of the inflammatory responses. We found that inflammatory cytokines were increased in the culture supernatant, when mouse monolayer cells were infected with the herpes family viruses in vitro. Inflammatory cytokines such as IFN and IL-1 were produced by immune cells at initial infection phase and then, fibroblasts which are present around the tooth precursor cells, are affected by these cytokines. These results suggested that the formation of a tooth may be influenced by inflammatory cytokines from immune cells.
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