Effect of osteocyte in TNF-a-induced osteoclast formation

• Project/Area Number: 24593075
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tohoku University
• Principal Investigator: KITAURA Hideki 東北大学, 歯学研究科(研究院), 准教授 (60295087)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Teruko 東北大学, 大学院歯学研究科, 教授 (00127250) ; TAKESITA Nobuo 東北大学, 大学院歯学研究科, 助教 (50431515) ; SEIRYU Masahiro 東北大学, 大学院歯学研究科, 助教 (80510023)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 破骨細胞 / 骨細胞 / TNF-α / TNF / サイトカイン / RANKL

Outline of Final Research Achievements

We purified osteocytes from mouse carvariae by using collagenase and EDTA after removing soft tissues. We analyzed the purification of osteocyte by quantified expression level of DMP-1 with real-time PCR. We found that fraction 5 maximally included osteocytes. We cultured the cells in fraction 5 as osteocyte with TNF-α in α-MEM. Total RNA was isolated from adherent cells. We quantified expression level of osteoclast related genes. We found that expression of RANKL was increased in osteocytes cultured with TNF-α.

Research Products

• [Journal Article] Muramyl dipeptide enhances lipopolysaccharide-induced osteoclast formation and bone resorption through increased RANKL expression in stromal cells. (2015)
  • Author(s): Ishida M, Kitaura H, Kimura K, Sugisawa H, Aonuma T, Takada H, Takano-Yamamoto T
  • Journal Title: J. Immunol. Res. Volume: 1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] IL-12 Inhibits Lipopolysaccharide Stimulated Osteoclastogenesis in mice. (2015)
  • Author(s): Yoshimatsu, M., Kitaura, H., Fujimura, Y., Kohara, H., Morita, Y., Yoshida, N
  • Journal Title: J. Immunol. Res. Volume: 1
  • NAID: 120006987060
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intra-articular administration of an antibody against CFS-1 receptor reduces pain-related behaviors and inflammation in CFA-induced knee arthritis. (2015)
  • Author(s): lvarado-Vazquez PA., Morado-Urbina CE., Castaneda-Corral G., Acosta-Gonzalez RI., Kitaura, H., Kimura, K., Takano-Yamamoto T., Jimanez-Andrade JM
  • Journal Title: Neurosci. Lett. Volume: 584 Pages: 39-44
  • DOI: 10.1016/j.neulet.2014.09.053
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of Interleukin-4 on orthodontic tooth movement and associated root resorption. (2015)
  • Author(s): Hakami ZW., Kitaura, H., Kimura, K., Ishida, M., Sugisawa, H., Ida, H., Takano-Yamamoto T
  • Journal Title: Eur J Orthod. Volume: 37 Issue: 1 Pages: 87-94
  • DOI: 10.1093/ejo/cju016
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between sleep bruxism and sleep respiratory events in patients with obstructive sleep apnea syndrome. (2014)
  • Author(s): Hosoya H, Kitaura H, Hashimoto T, Ito M, Kinbara M, Deguchi T, Irokawa T, Ohisa N, Ogawa H, Takano-Yamamoto T
  • Journal Title: Sleep Breath Volume: Feb Issue: 4 Pages: 837-844
  • DOI: 10.1007/s11325-014-0953-5
  • Peer Reviewed
• [Journal Article] Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway (2014)
  • Author(s): K Hoshi, H Kawaki, I Takahashi, N Takeshita, M Seiryu, S A Murshid, T Masuda, T Anada, R Kato, H Kitaura, O Suzuki, T Takano-Yamamoto
  • Journal Title: J Bone Miner Res Volume: 29 Issue: 5 Pages: 1244-1257
  • DOI: 10.1002/jbmr.2115
  • NAID: 130004695790
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Combination of tumor necrosis factor α and interleukin-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in vivo (2014)
  • Author(s): Yokota K, Sato K, Miyazaki T, Kitaura H, Kayama H, Miyoshi F, Araki Y, Akiyama Y, Takeda K, Mimura T.
  • Journal Title: Arthritis Rheumatol. Volume: 66 Issue: 1 Pages: 121-129
  • DOI: 10.1002/art.38218
  • Peer Reviewed
• [Journal Article] An anti-c-Fms antibody inhibits osteoclastogenesis in a mouse periodontitis model (2014)
  • Author(s): Kimura K, Kitaura H, Fujii T, Ishida M, Hakami Z, Takano-Yamamoto T
  • Journal Title: Oral Diseases. Volume: 20(3) (in press) Issue: 3 Pages: 319-24
  • DOI: 10.1111/odi.12117
  • Peer Reviewed
• [Journal Article] Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane (2014)
  • Author(s): Kitaura H, Kimura K, Ishida M, Sugisawa H, Kohara H, Yoshimatsu M, Takano-Yamamoto T
  • Journal Title: Scientific World Journal Volume: 19 Pages: 1-7
  • DOI: 10.1155/2014/617032
  • Peer Reviewed / Open Access
• [Journal Article] Histochemical Characteristics of Glycoproteins during Rat Palatine Gland Development. (2014)
  • Author(s): Hakami Z., Kitaura, H., Honma, S., Wakisaka, S., Takano-Yamamoto T
  • Journal Title: Interface Oral Health Science 2014 Volume: 1 Pages: 183-192
  • DOI: 10.1007/978-4-431-55192-8_15
  • ISBN: 9784431551256, 9784431551928
  • Open Access
• [Journal Article] The role of Th1 cytokines on mechanical loading-induced osteoclastogenesis and bone resorption. (2014)
  • Author(s): Kitaura, H., Kimura, K., Ishida, M., Hakami Z., Sugisawa, H., Saeed J., Kohara H., Yoshimatsu M., Takano-Yamamoto T
  • Journal Title: Interface Oral Health Science 2014 Volume: 1 Pages: 269-279
  • DOI: 10.1007/978-4-431-55192-8_23
  • ISBN: 9784431551256, 9784431551928
  • Open Access
• [Journal Article] Effect of macrophage colony-stimulating factor receptor c-Fms antibody on lipopolysaccharide-induced pathological osteoclastogenesis and bone resorption. (2014)
  • Author(s): Kimura, K., Kitaura, H., Ishida, M., Hakami Z., Saeed J., Sugisawa, H., Takano-Yamamoto T
  • Journal Title: Interface Oral Health Science 2014 Volume: 1 Pages: 259-267
  • DOI: 10.1007/978-4-431-55192-8_22
  • ISBN: 9784431551256, 9784431551928
  • Open Access
• [Journal Article] 東北大学矯正歯科における長期咬合管理について (2014)
  • Author(s): 北浦英樹、山本照子
  • Journal Title: 東北矯正歯科学会雑誌 Volume: 22 Pages: 51-55
• [Journal Article] Effect of Interleukin-4 on orthodontic tooth movement and associated root resorption. (2014)
  • Author(s): Hakami ZW., Kitaura, H., Kimura, K., Ishida, M., Sugisawa, H., Ida, H., Takano-Yamamoto T
  • Journal Title: Eur. J. Orthod. Volume: in press
  • Peer Reviewed
• [Journal Article] 歯根吸収の生物学的メカニズムと制御について (2014)
  • Author(s): 北浦英樹、山本照子
  • Journal Title: 臨床かのための矯正YEARSBOOK2014 Volume: in press
• [Journal Article] Lectin histochemistry of palatine glands in the developing rat (2013)
  • Author(s): Hakami ZW., Kitaura, H., Honma, S., Wakisaka, S., Takano-Yamamoto T
  • Journal Title: Acta Histochemica Volume: (in press) Issue: 4 Pages: 596-605
  • DOI: 10.1016/j.acthis.2013.11.002
  • Peer Reviewed
• [Journal Article] Immunological Expression of Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and PAC1 in the Periodontal Ligament After Tooth Luxation (2013)
  • Author(s): Nonaka S, Kitaura H, Kimura K, Ishida M, Takano-Yamamoto T
  • Journal Title: Cell Mol Neurobiol Volume: 33(7) Issue: 7 Pages: 885-92
  • DOI: 10.1007/s10571-013-9953-4
  • Peer Reviewed
• [Journal Article] Immunological reaction in TNF- α-mediated osteoclast formation and bone resorption in vitro and in vivo (2013)
  • Author(s): Kitaura H, Kimura K, Ishida M, Kohara H, Yoshimatsu M, Takano-Yamamoto T
  • Journal Title: Clin Dev Immunol Volume: 2013 Pages: 1-8
  • DOI: 10.1155/2013/181849
  • Peer Reviewed
• [Journal Article] 新の骨粗鬆症学 ―骨粗鬆症の最新知見― TNF-α (2013)
  • Author(s): 北浦英樹
  • Journal Title: 日本臨床 Volume: 71 Pages: 141-145
• [Journal Article] 東北大学矯正歯科における最近の臨床調査 (2013)
  • Author(s): 北浦英樹、千田透子、細谷尚史、山本照子
  • Journal Title: 東北矯正歯科学会雑誌 Volume: 21 Pages: 69-72
• [Journal Article] An anti-c-Fms antibody inhibits osteoclastogenesis in a mouse periodontitis model. (2013)
  • Author(s): Kimura, K., Kitaura, H., Fujii, T., Ishida, M., Hakami ZW., Takano-Yamamoto T
  • Journal Title: Oral Diseases. Volume: 19
  • Peer Reviewed
• [Journal Article] 最新の骨粗鬆症学 ―骨粗鬆症の最新知見― TNF-α (2013)
  • Author(s): 北浦英樹
  • Journal Title: 日本臨床 Volume: 71 Pages: 141-145
• [Journal Article] Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice (2012)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimuar Y, Kohara H, Morita Y, Eguchi T, Yoshida N
  • Journal Title: Arch Oral Biol Volume: 57 Issue: 1 Pages: 36-43
  • DOI: 10.1016/j.archoralbio.2011.07.006
  • Peer Reviewed
• [Journal Article] Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo (2012)
  • Author(s): Kimura K, Kitaura H, Fujii T, Hakami ZW, Takano-Yamamoto T
  • Journal Title: FEMS Immunol Med Microbiol Volume: 64 Issue: 2 Pages: 219-227
  • DOI: 10.1111/j.1574-695x.2011.00888.x
  • Peer Reviewed
• [Journal Article] Comparative Proteomic Analysis of a Cytosolic Fraction from β3 Integrin-deficient Cells. (2012)
  • Author(s): Bush, JA., Kitaura, H., Ma, Y., Teitelbaum, SL., Ross, FP., Smith JW.
  • Journal Title: Cancer Genomics Proteomics. Volume: 9 Pages: 1-13
  • Peer Reviewed
• [Journal Article] Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass. (2012)
  • Author(s): Masuyama R
  • Journal Title: Journal of bone and mineral research Volume: 27 Issue: 8 Pages: 1708-1721
  • DOI: 10.1002/jbmr.1629
  • Peer Reviewed
• [Journal Article] Inhibitory effect of IFN-γ on experimental toothmovement in mice. (2012)
  • Author(s): Kohara, H., Kitaura, H., Yoshimatsu, M., Fujimura, Y., Morita, Y., Eguchi, T., Yoshida, N.
  • Journal Title: J. Interferon Cytokine. Res. Volume: 32 Issue: 9 Pages: 426-431
  • DOI: 10.1089/jir.2011.0124
  • Peer Reviewed
• [Journal Article] IL-4 inhibits TNF-α-mediated osteoclast formation by inhibition of RANKL expression in TNF-α- activated stromal cells and direct inhibition of TNF-α-activated osteoclast precursors via a T-cell- independent mechanism in vivo (2012)
  • Author(s): Fujii T, Kitaura H, Kimura K, Hakami ZW, Takano-Yamamoto
  • Journal Title: Bone Volume: 51 Issue: 4 Pages: 771-780
  • DOI: 10.1016/j.bone.2012.06.024
  • Peer Reviewed
• [Journal Article] 東北大学病院における東日本大震災後の矯正歯科患者の実態調査 (2012)
  • Author(s): 北浦英樹、出口徹、池田悦子、竹下信郎、橋本隆志、清流正弘、伊藤麻卯、木村桂介、藤井俊哉、石田匡彦、山本照子
  • Journal Title: 東北大学歯学雑誌 Volume: 31 Pages: 1-7
  • Peer Reviewed
• [Journal Article] 顎関節症、シザーズバイトおよび叢生を伴う骨格性I級アングルII級の顔面非対称に対しアンカースクリューを用いて改善した症例 (2012)
  • Author(s): 千田透子、出口徹、渡辺壽子、北浦英樹、山本照子
  • Journal Title: 東北矯正歯科学会雑誌 Volume: 20 Pages: 31-45
  • Peer Reviewed
• [Presentation] Analysis of effect of IL-4 on mechanical loading-induced osteoclast formation and bone resorption. (2014)
  • Author(s): Kitaura H, Hakami Z., Kimura K, Ishida M, Sugisawa H, Takano-Yamamoto T.
  • Organizer: The 62nd Annual Meeting of Japanese Association for Dental Research,
  • Place of Presentation: Osaka
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] Analysis of the corrosion resistance of titanium nitride coating on orthodontic wires. (2014)
  • Author(s): Sugisawa H., Kitaura H., Ueda K., Kimura K., Ishida M., Takano-Yamamoto T.
  • Organizer: The 62nd Annual Meeting of Japanese Association for Dental Research,
  • Place of Presentation: Osaka
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] Effect of muramyl dipeptide on LPS-induced osteoclast formation and bone resorption. (2014)
  • Author(s): Ishida M, Kitaura H, Kimura K, Sugisawa H, Aonuma T, Takada H, Takano-Yamamoto T
  • Organizer: The 62nd Annual Meeting of Japanese Association for Dental Research,
  • Place of Presentation: Osaka
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] 矯正学的歯の移動におけるIL-4の効果 (2014)
  • Author(s): 北浦英樹、ザキウェリハカミ、木村桂介、石田匡彦、杉澤晴紀、井田裕人、ジャファリサイード、山本照子
  • Organizer: 第73回日本矯正歯科学会
  • Place of Presentation: 幕張
  • Year and Date: 2014-10-20 – 2014-10-22
• [Presentation] LPSが引き起こす破骨細胞形成および骨吸収に対するMDPの作用の検討 (2014)
  • Author(s): 石田匡彦、北浦英樹、木村桂介、ザキウェリハカミ、杉澤晴紀、ジャファリサイード、高田春比古、山本照子
  • Organizer: 第73回日本矯正歯科学会
  • Place of Presentation: 幕張
  • Year and Date: 2014-10-20 – 2014-10-22
• [Presentation] 前頭面からみた咬合平面傾斜が生活の質、顎機能の問題および顎顔面非対称に対する認識に及ぼす影響 (2014)
  • Author(s): 黒木毅、北浦英樹、出口徹、小林考敬、小原紀明、山本照子
  • Organizer: 第73回日本矯正歯科学会
  • Place of Presentation: 幕張
  • Year and Date: 2014-10-20 – 2014-10-22
• [Presentation] Effect of IL-4 on mechanical loading-induced osteoclastogenesis and bone resorption. (2014)
  • Author(s): Kitaura H, Hakami Z., Kimura K, Ishida M, Saeed J, Sugisawa H, Takano-Yamamoto T
  • Organizer: The 36th Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Houston, U.S.A.
  • Year and Date: 2014-09-12 – 2014-09-15
• [Presentation] Muramyl dipeptide enhances Lipopolysaccharide-induced osteoclast formation and bone resorption by enhance of RANKL expression. (2014)
  • Author(s): Ishida M, Kitaura H, Kimura K, Saeed J, Sugisawa H, Takada H., Takano-Yamamoto T.
  • Organizer: The 36th Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Houston, U.S.A.
  • Year and Date: 2014-09-12 – 2014-09-15
• [Presentation] The corrosion resistance of Titanium Nitride (TiN) plating on an orthodontic wires. (2014)
  • Author(s): Sugisawa H., Kitaura H., Ueda K., Kimura K., Ishida M., Saeed J., Ochi Y, Takano-Yamamoto T
  • Organizer: 9th International Workshop on Biomaterials in Interface Science. Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2014
  • Place of Presentation: Miyagi
  • Year and Date: 2014-08-26 – 2014-08-27
• [Presentation] LPS誘導病的骨吸収に対するMDPの作用の検討 (2014)
  • Author(s): 石田匡彦、北浦英樹、木村桂介、杉澤晴紀、山本照子
  • Organizer: 第32回日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] Macrophage colony-stimulating factor中和による機械的荷重により誘導される破骨細胞形成および破歯細胞形成に対する抑制効果 (2014)
  • Author(s): 北浦英樹、木村桂介、石田匡彦、ハカミ ザキ、サイード ジャファリ、杉澤 晴紀、小原悠、吉松昌子、山本照子
  • Organizer: 第53回日本生体医工学会
  • Place of Presentation: 仙台
  • Year and Date: 2014-06-24 – 2014-06-26
• [Presentation] 圧縮力負荷に伴い骨細胞より産生されたCCN2はERK1/2経路を介しアポトーシスを誘導する (2014)
  • Author(s): 星健治、川木晴美、高橋一郎、竹下信郎、清流正弘、Sakhr A Murshid、益田泰輔、穴田貴久、加藤龍史、北浦英樹、鈴木治、山本照子
  • Organizer: 第53回日本生体医工学会
  • Place of Presentation: 仙台
  • Year and Date: 2014-06-24 – 2014-06-26
• [Presentation] 東北大学矯正歯科における長期咬合管理について. (2014)
  • Author(s): 北浦英樹
  • Organizer: 第30回東北矯正歯科学会大会
  • Place of Presentation: 福島
  • Year and Date: 2014-05-24 – 2014-05-25
  • Invited
• [Presentation] Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway. (2014)
  • Author(s): Hoshi, K.,Kawaki H., Takahashi I., Takeshita, N., Seiryu M., Murshid SA., Masuda T., Anada T., Kato R., Kitaura H., Suzuki O., Takano-Yamamoto T
  • Organizer: ISMB 2014
  • Place of Presentation: Okayama
  • Year and Date: 2014-05-20 – 2014-05-23
• [Presentation] Effect of Th1 cytokines on mechanical force loading induced osteoclast formation and bone resorption. (2014)
  • Author(s): Kitaura H, Kimura K, Ishida M, Hakami Z., Saeed J, Sugisawa H, Kohara H, Yoshimatsu M, Takano-Yamamoto T.
  • Organizer: The 5th International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai, Japan.
• [Presentation] M-CSF receptor c-Fms antibidy inhibits pathological osteoclast formation in vivo. (2014)
  • Author(s): Kimura, K, Kitaura, H, Ishida M, Hakami Z., Saeed J, Sugisawa H, Takano-Yamamoto T
  • Organizer: The 5th International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai, Japan.
• [Presentation] Glycohistochemical observation of the developing rat palatine glands: heterogeneous distribution between anterior and posterior side glands of adult soft palate. (2014)
  • Author(s): Hakami Z., Kitaura, H.,Honma, S., Wakisaka S., Takano-Yamamoto T
  • Organizer: The 5th International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai, Japan.
• [Presentation] IL-4 inhibits TNF-α-mediated osteoclast formation via a T-cell-dependent mechanism in vitro and in vivo (2013)
  • Author(s): Kitaura H, Kimura K, Hakami ZW, Ishida M, Sugisawa H, Takano-Yamamoto T.
  • Organizer: NIH Tohoku University JSPS Symposium
  • Place of Presentation: Sendai, Japan.
• [Presentation] Neutralization of macrophage colony-stimulating factor inhibits pathological osteoclastogenesis in vitro and in vivo. (2013)
  • Author(s): Kimura K, Kitaura H, Hakami ZW, Ishida M, Sugisawa H, Takano-Yamamoto T
  • Organizer: NIH Tohoku University JSPS Symposium
  • Place of Presentation: Sendai, Japan.
• [Presentation] Heterogeneous lectin binding pattern between anterior and posterior portions of the palatine glands of adult rat. (2013)
  • Author(s): Hakami ZW, Kitaura H, Honma S, Wakisaka S, Takano-Yamamoto T
  • Organizer: NIH Tohoku University JSPS Symposium
  • Place of Presentation: Sendai, Japan.
• [Presentation] Histochemical evaluation of glycoproteins in the developing rat palatine glands. (2013)
  • Author(s): Hakami ZW, Kitaura H, Honma S, Wakisaka S, Takano-Yamamoto T
  • Organizer: The 2nd Meeting of the International Association for Dental Research-Asia Pacific Region 2013
  • Place of Presentation: Bangkok, Thailand.
• [Presentation] IFN-γ inhibits TNF-α-mediated osteoclast formation in vitro and in vivo and induces apoptosis by Fas/Fas ligand interactions. (2013)
  • Author(s): Kitaura H, Kimura K, Ishida M, Sugisawa H, Saeed J, Hakami ZW, Takano-Yamamoto T.
  • Organizer: 8th International Workshop on Biomaterials in Interface Science. Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2013
  • Place of Presentation: Zao, Miyagi, Japan.
• [Presentation] Developmental glycoproteins modification and distribution in rat palatine glsnds. (2013)
  • Author(s): Hakami Z., Kitaura, H.,Honma, S., Wakisaka S., Takano-Yamamoto T
  • Organizer: The 72th Annual Meeting of the Japanese Orthodontic Society.
  • Place of Presentation: Mastumoto, Japan.
• [Presentation] Treatment of Class III malocclusion case by distal mandibular molar movement with orthodontic anchored screws (2013)
  • Author(s): Jafari S., Aonuma T., Kitaura, H., Oikawa H., Hashimoto T., Takano-Yamamoto T
  • Organizer: The 72th Annual Meeting of the Japanese Orthodontic Society.
  • Place of Presentation: Mastumoto, Japan.
• [Presentation] 東北大学病院矯正歯科における最近の臨床調査. (2013)
  • Author(s): 北浦英樹
  • Organizer: 第29回東北矯正歯科学会大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 歯根吸収の生物学的メカニズムと制御 (2013)
  • Author(s): 北浦英樹
  • Organizer: 第72回日本矯正歯科学会大会
  • Place of Presentation: 松本
  • Invited
• [Presentation] 咬合平面傾斜が及ぼす顎顔面形態の非対称性の認識について (2013)
  • Author(s): 北浦英樹
  • Organizer: 第4回Oral Function Mesh Collaboration
  • Place of Presentation: 郡山
  • Invited
• [Presentation] 日中の眠気と上軌道組織形態の関連性について (2013)
  • Author(s): 千田透子、ジャファリサイード、北浦英樹、山本照子
  • Organizer: 第29回東北矯正歯科学会大会
  • Place of Presentation: 青森
• [Presentation] 歯根膜侵襲刺激後の神経ペプタイドpituitary adenylate cyclase activating polypeptide(PACAP)の発現について (2013)
  • Author(s): 北浦英樹、木村桂介、石田匡彦、山本照子
  • Organizer: 第55回歯科基礎医学会
  • Place of Presentation: 岡山
• [Presentation] LPSの破骨細胞形成に対するMDPの作用の検討 (2013)
  • Author(s): 石田匡彦、北浦英樹、木村桂介、高田春比古、山本照子
  • Organizer: 第55回歯科基礎医学会
  • Place of Presentation: 岡山
• [Presentation] 侵襲刺激後の神経ペプタイドpituitary adenylate cyclase activating polypeptide(PACAP)の歯根膜での発現 (2013)
  • Author(s): 北浦英樹、野中紗弥子、出口徹、木村桂介、石田匡彦、山本照子
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] LPS誘導破骨細胞形成および骨吸収に対するMDPの作用の検討 (2013)
  • Author(s): 石田匡彦、北浦英樹、木村桂介、ハカミザキウェリ、杉澤晴紀、ジャファリサイード、高田春比古、山本照子
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] LPSによる破骨細胞形成に対するIL-12の抑制機序 (2013)
  • Author(s): 吉松昌子、北浦英樹、藤村裕治、小原悠、森田幸子、吉田教明
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] 矯正学的歯の移動時におこる歯根吸収に対するINF-γの作用について (2013)
  • Author(s): 小原悠、北浦英樹、吉松昌子、藤村裕治、森田幸子、吉田教明
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] マウス歯周病モデルを用いた破骨細胞形成および骨吸収に対する抗c-fms抗体の抑制効果の検討 (2013)
  • Author(s): 木村桂介、北浦英樹、石田匡彦、ハカミザキウェリ、杉澤晴紀、ジャファリサイード、 山本照子
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] 日中の眠気傾向と顎顔面形態の関連性について (2013)
  • Author(s): 千田透子、ジャファリサイード、北浦英樹、山本照子
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] IL-4 inhibits TNF-α-mediated osteoclast formation by inhibition of RANKL expression in TNF-α-activated stromal cells and direct inhibition of TNF-α-activated osteoclast precursors. (2012)
  • Author(s): Kitaura H, Fujii T, Kimura K, Ishida M, Hakami Z, Takano-Yamamoto T.
  • Organizer: The 34th Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Minneapolis, U.S.A.
• [Presentation] Neutralization of macrophage colony-stimulating factor inhibits lipopolysaccharide-induced osteoclastogenesis in vivo. (2012)
  • Author(s): Kimura, K., Kitaura, H., Fujii, T., Ishida M, Hakami Z., Takano-Yamamoto T
  • Organizer: The 34th Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Minneapolis, U.S.A.
• [Presentation] IFN-γ inhibits mechanical stress-induced osteoclastogenesis and bone resorption. (2012)
  • Author(s): Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N.
  • Organizer: The 34th Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Minneapolis, U.S.A.
• [Presentation] Effects of IL-12 on mechanical loading induced bone resorption. (2012)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N.
  • Organizer: The 34th Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Minneapolis, U.S.A.
• [Presentation] Calcium/calmodulin-signaling regulates TRPV4 action by the process supporting myosin IIa association in osteoclasts. (2012)
  • Author(s): Masuyama R, Mizuno A, Kajiya H, Kitaura H, Okabe K, Komori T.
  • Organizer: The 34th Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Minneapolis, U.S.A.
• [Presentation] 歯の移動の生物学的メカニズムと制御. (2012)
  • Author(s): 北浦英樹
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡
  • Invited
• [Presentation] 顎顔面形態と睡眠の関連性について (2012)
  • Author(s): 北浦英樹
  • Organizer: 第6回東北矯正歯科学会秋期セミナー
  • Place of Presentation: 仙台
  • Invited
• [Presentation] イオンプレーティング法による金属アレルギー矯正材料の開発 (2012)
  • Author(s): 北浦英樹、木村桂介、藤井俊哉、石田匡彦、山本照子
  • Organizer: 第28回東北矯正歯科学会大会
  • Place of Presentation: 仙台
• [Presentation] LPSにより誘導される骨吸収に対する抗c-fms抗体の抑制作用の検討 (2012)
  • Author(s): 木村桂介、北浦英樹、藤井俊哉、石田匡彦、ザキウェリハカミ、山本照子
  • Organizer: 第60回東北大学歯学会
  • Place of Presentation: 仙台
• [Presentation] TNF-αによる破骨細胞形成におけるIL-4の影響のin vivoでの検討 (2012)
  • Author(s): 北浦英樹、木村桂介、石田匡彦、ザキウェリハカミ、山本照子
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 東京
• [Presentation] メカニカルストレスに対するIFN-γの発現およびその影響 (2012)
  • Author(s): 小原悠、北浦英樹、吉松昌子、森田幸子、藤村裕治
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 東京
• [Presentation] LPS誘導骨吸収に対する抗c-fms抗体の抑制作用の検討 (2012)
  • Author(s): 木村桂介、北浦英樹、石田匡彦、ザキウェリハカミ、山本照子
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 東京
• [Presentation] IL-12がメカニカルストレスによる骨吸収に及ぼす影響 (2012)
  • Author(s): 吉松昌子、北浦英樹、小原悠、森田幸子、藤村裕治
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 東京
• [Presentation] メカニカルストレスに対する歯根周囲組織におけるINF-γの影響 (2012)
  • Author(s): 小原悠、北浦英樹、吉松昌子、藤村裕治、森田幸子、吉田教明
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡
• [Presentation] IL-12がLPS誘導破骨細胞形成に及ぼす影響 (2012)
  • Author(s): 吉松昌子、北浦英樹、藤村裕治、小原悠、森田幸子、吉田教明
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡
• [Presentation] IL-4のTNF-αによるRANKLおよびDC-STAMP発現のin vivoのおける抑制効果について (2012)
  • Author(s): 北浦英樹、藤井俊哉、木村桂介、石田匡彦、ハカミザキウェリ、山本照子
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡
• [Presentation] M-CSF作用抑制による病的骨吸収に対する制御の検討 (2012)
  • Author(s): 木村桂介、北浦英樹、藤井俊哉、石田匡彦、ハカミザキウェリ、山本照子
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡
• [Presentation] IL-18による矯正学的歯の移動抑制作用におけるT細胞関与の検討 (2012)
  • Author(s): 森田幸子、北浦英樹、吉松昌子、藤村裕治、小原悠、吉田教明
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡
• [Presentation] 咬筋切除術を施した咬筋肥大症を伴う患者の機能的改善について (2012)
  • Author(s): 鈴木章裕、北浦英樹、石田匡彦、橋本隆志、出口徹、山本照子
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡
• [Book] 歯根吸収の生物学的メカニズムと制御について 臨床家のための矯正YEARSBOOK2014 原点回帰 -矯正の未来を見据えて- (2014)
  • Author(s): 北浦英樹、山本照子、他
  • Total Pages: 186
  • Publisher: クインテッセンス出版