| Project/Area Number |
24593076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
DEGUCHI Toru 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (30346457)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Teruko 東北大学, 大学院歯学研究科, 教授 (00127250)
SEIRYU Masahiro 東北大学, 大学院歯学研究科, 助教 (80510023)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 疼痛抑制 / CO2レーザー |
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| Outline of Final Research Achievements |
Results indicated that astrocyte and glia increased after 3 days of experimental tooth movement, the most increase was observed after 5 days, and returned to the control level at 14 days after in the rat MDH.Then, we analyzed the co-localization with c-fos that is known as a marker for pain with astrocyte and glia.The most increase of c-fos and astrocyte and glia co-localization was observed after 5 days at both caudalis and orals.Thus, it was indicated that astrocyte and glia plays an important role in delayed pain during tooth movement.In addition, there was a significant decrease in c-fos expression after CO2 laser irradiation but no change was observed for the increased astrocyte and glia after 1-3 days of tooth movement.
Therefore, the effect of CO2 laser is limited to mainly acute but not delayed pain observed during orthodontic tooth movement.
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