| Project/Area Number |
24593078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Iwate Medical University (2014)
Tohoku University (2012-2013) |
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Principal Investigator |
MARUYA Yuriko 岩手医科大学, 歯学部, 講師 (60400389)
|
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takashi 東北大学, 歯学研究科, 准教授 (90585324)
IWAMOTO Tsutomu 徳島大学, ヘルスバイオサイエンス研究部, 教授 (90346916)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 歯の再生 / 骨形成因子 |
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| Outline of Final Research Achievements |
Growth/Differentiation Factor-5 (GDF-5) is a member of the bone morphogenetic protein and promotes formation of bones and cartilages. It has been reported that GDF-5 gene is expressed in oral region. However, the roles of GDF-5 in the differentiation of dental pulp cells are unknown. Thus, we investigated the effect of GDF-5 on the differentiation of dental pulp stem cell.
GDF-5 promoted production of molecules characteristic for odontoblastic phenotype.And gene expression of VEGF increased in the presence of GDF-5. These findings suggested that GDF-5 promotes differentiation of dental pulp stem cell to odontblast.In addition, possibility to become the effective molecules in reproducing pulp tissue from dental pulp stem cell was suggested .
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