| Project/Area Number |
24593079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKAYASU Mari 東京大学, 医学部附属病院, 特任臨床医 (10610941)
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| Co-Investigator(Kenkyū-buntansha) |
HAKETA Yoshiyuki 明海大学, 歯学部, 教授 (90164772)
SUSAMI Takafumi 東京大学, 医学部, 准教授 (80179184)
NAGAHAMA Kohei 東京大学, 医学部, 助教 (80587775)
YANO Fumiko 東京大学, 医学(系)研究科(研究院), 助教 (80529040)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 破骨細胞 / lipid raft / 骨代謝 / ＬＤＬ / コレステロール / LDL受容体 |
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| Outline of Final Research Achievements |
Disruption of the balance between osteoblastic bone formation and osteoclastic bone resorption causes various bone disorders.This study indicate that osteoclast differentiation is highly dependent of exogenous cholesterol and that the decrease in intracellular cholesterol level due to LDLR deficiency results in the reduction of cell-cell-fusion of preosteoclasts due to the impaired trafficking of osteoclast fusion proteins such as DC-STAMP and Atp6v0d2 into the plasma membrane. The study presented here demonstrates the close relationship between bone and lipid metabolisms and a novel mechanism for osteoclast differentiation.
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