Investigation of the etiology of Parry-Romberg syndrome using induced pluripotent stem cells
| Project/Area Number |
24593091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
KAWANABE Noriaki 岡山大学, 医歯(薬)学総合研究科, 准教授 (00397879)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGITA Takeshi 岡山大学, 大学病院, 講師 (90534793)
SUMIYOSHI Kumi 岡山大学, 医歯(薬)学総合研究科, 助教 (80625161)
YAMASHIRO Takashi 大阪大学, 歯学研究科(研究院), 教授 (70294428)
SUGAWARA Yasuyo 岡山大学, 大学病院, 講師 (70379775)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ロンベルグ症候群 / 歯根膜細胞 / 人工多能生幹細胞（ｉＰＳ細胞） / 人工多能性幹細胞（ｉＰＳ細胞） / 人工多能性幹細胞（iPS細胞） |
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| Outline of Final Research Achievements |
In the present study, we investigated the stem cell property of periodontal cells derived from Parry-Romberg syndrome patient (Romberg PDL cells). Romberg PDL cells expressed significantly higher levels of ICAM-1, NCAM-1 and SSEA-4 compared to normal PDL cells. In addition, adipogenic and osteogenic differentiation potentials of Romberg PDL cells were inferior to that of normal PDL cells. Pulsing neutral antibodies against ICAM-1, NCAM-1 and SSEA-4 improved their adipogenic and osteogenic differentiation potentials. Taken together, facilitating expression of ICAM-1, NCAM-1 and SSEA-4 appears to cause the phenotype of Parry-Romberg syndrome.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Gap junction-mediated communication in human periodontal ligament cells2013
Author(s)
Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T and Yamashiro T
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Journal Title
JDR
Volume: 92(7)
Issue: 7
Pages: 635-40
DOI
Related Report
Peer Reviewed
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