Relationship between the change of extracellular matrix due to allergy and the orthodontic force induced root resorption

• Project/Area Number: 24593095
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Kyushu University
• Principal Investigator: IOI Hideki 九州大学, 大学病院, 講師 (10274474)
• Co-Investigator(Kenkyū-buntansha): KIDO Mizuho 九州大学, 歯学研究科(研究院), 准教授 (60253457) ; 高橋 一郎 九州大学, 歯学研究科(研究院), 教授 (70241643)
• Co-Investigator(Renkei-kenkyūsha): TAKAHASHI Ichiro 九州大学, 歯学研究科(研究院), 教授 (70241643)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 歯根吸収 / アレルギー / 歯の移動 / OVA / MMP / TIMP

Outline of Final Research Achievements

We found the enhanced expression of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 on the surface of the periodontal membrane and alveolar bone in the OVA with orthodontic force group. The expression level of TIMP-1 was significantly higher in the OVA with orthodontic force group than in the other groups after 24 hours of orthodontic force. The same tendencies were observed for the expression levels of MMP-9 and TIMP-2. The expression levels of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 were suppressed due to Aspirin administration. However, no significant effect by the OVA observed in the 24 hours orthodontic force induced rats. Further detailed study would be necessary for the elucidation.

Research Products

• [Journal Article] Effect of allergen sensitization on external root resorption. (2013)
  • Author(s): Murata N, Ioi H, Ouchi M, Takao T, Oida H, Aijima R, Yamaza T, Kido MA
  • Journal Title: Joumal of Dental Research Volume: 92 Issue: 7 Pages: 641-647
  • DOI: 10.1177/0022034513488787
  • Peer Reviewed
• [Presentation] 矯正的歯の移動時におけるアレルギー誘導性歯根吸収促進メカニズムの解明 (2014)
  • Author(s): 村田直久、五百井秀樹、大内雅博、城戸瑞穂、高橋一郎
  • Organizer: 日本矯正歯科学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2014-10-20 – 2014-10-22
• [Presentation] 矯正的歯の移動時におけるアレルギー誘導性歯根吸収促進機構 (2013)
  • Author(s): 村田直久、五百井秀樹、大内雅博、合島怜央奈、沖雄二、山座孝義、高橋一郎、城戸瑞穂
  • Organizer: 歯科基礎医学会学術大会
  • Place of Presentation: 岡山
• [Presentation] Novel insight into mechanisms of bone loss from allergic inflammation using experimental mouse model
  • Author(s): Ouchi M, Hatakeyama J, Murata N, Yoshinari M, Aijima R, Ioi H, Takahashi I, Kido M
  • Organizer: 2nd joint meeting of the international bone and mineral society and the Japanese society for bone and mineral research
  • Place of Presentation: Kobe
• [Book] Orthodontics (2015)
  • Author(s): Hideki Ioi, Mizuho A. Kido, Masato Nishioka, Mikari Asakawa, Ryusuke Muroya, Ichiro Takahashi
  • Total Pages: 22
  • Publisher: INTECH