The effects of the orthognathic surgical treatment on upper gastrointestinal function, autonomic nervous and endocrine function.

• Project/Area Number: 24593101
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: University of Miyazaki
• Principal Investigator: YOSHIDA Maho 宮崎大学, 医学部, 医員 (10535785)
• Co-Investigator(Kenkyū-buntansha): YOSHIOKA Izumi 九州歯科大学, 歯学部, 教授 (10305823) ; NAGATA Junko 宮崎大学, 医学部, 講師 (50264429) ; NOMURA Kaori 宮崎大学, 医学部, 医員 (60626141) ; MATSUMOTO Nobuhiro 宮崎大学, 医学部, 助教 (70418838)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 顎変形症 / 下顎前突症 / 顎口腔機能 / 消化管活動 / 睡眠 / 自律神経活動 / 外科的矯正治療 / 消化管運動 / 上部消化管機能

Outline of Final Research Achievements

The purpose of this study is inspection of the hypotheses that upper digestive tract function, autonomic nervous and endocrine function are improved by the improving of the skeletal Class III malocclusion using orthognathic surgical treatment. Cross sectional and Prospective Study were conducted with the 10 Class III malocclusion patients and 10 normal occlusion subjects.
The Maximal voluntary bite force and the occlusal contact area were significantly smaller in the Class III group than in the control group. The Class III patients suggested by significantly higher degree of the Tmax of the 13C-acetate breath test, the LF/HF ratio and the irregularity of gastrointestinal activity rhythm, than for the normal occlusion subjects. After orthognathic surgical treatment, all these values were decreased. These findings suggest that the hypothesis mentioned above is right.

Research Products

• [Journal Article] Relationships between occlusal force and morphology using the feature elements of occlusal indices. (2013)
  • Author(s): Igawa,K., Nagata,J., Yamashita,Y.and Sakoda,S.
  • Journal Title: Journal of Japan Association of Dental Traumatology Volume: 9(1) Pages: 23-28
  • NAID: 40019989541
  • Peer Reviewed
• [Journal Article] Risk factors for breakage of biodegradable plate systems after bilateral sagittal split mandibular setback surgery. (2013)
  • Author(s): Yoshioka I, Igawa K, Nagata J, Yoshida M, Baba T, Ichiki T, Kondoh Y, Takamori K, Kashima K, Sakoda S.
  • Journal Title: Br J Oral Maxillofac Surg Volume: 印刷中 Issue: 4 Pages: 307-311
  • DOI: 10.1016/j.bjoms.2012.06.007
  • Peer Reviewed
• [Journal Article] sagittal split ramus osteotomy for patients with skeletal mandibular prognathism and open bite (2013)
  • Author(s): Yoshioka I, Tanaka T, Habu M, Oda M, Kodama M, Kokuryo S, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Seta Y, Fukudome Y, Tominaga K, Sakoda S, Morimoto Y.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 115 Issue: 4 Pages: 455-65
  • DOI: 10.1016/j.oooo.2012.06.010
  • Peer Reviewed
• [Presentation] 歯科でできる！? 睡眠障害の早期発見と治療 (2015)
  • Author(s): 永田順子
  • Organizer: 第27回日本小児口腔外科学会
  • Place of Presentation: シーガイアコンベンションセンター
  • Year and Date: 2015-11-07
  • Invited
• [Presentation] 小児の睡眠障害の診断と治療 (2015)
  • Author(s): 藤本（野村）かおり
  • Organizer: 第27回日本小児口腔外科学会
  • Place of Presentation: シーガイアコンベンションセンター
  • Year and Date: 2015-11-07
  • Invited
• [Presentation] 片側下顎頭過形成を伴う顔面非対称症に対して下顎枝矢状分割術後に咬合不正の再発 を認めて下顎頭切除術を行った1症例 (2015)
  • Author(s): 永田順子、温水佳世子、近藤雄大、井川加織、山下善弘
  • Organizer: 第28回日本顎関節学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-07-04 – 2015-07-05
• [Presentation] 睡眠時のブラキシズムが睡眠サイクルと 自律神経機能に及ぼす影響 (2012)
  • Author(s): 永田順子、吉田真穂、井川加織、 藤本かおり※）、鹿嶋光司、高森晃一、吉岡 泉、迫田隅男
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: インテックス大阪