Influence of autonomic nervous activity and gastrointestinal hormones on regulation of gastric activity by mastication
| Project/Area Number |
24593104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
HARUHITO Omure 鹿児島大学, 医歯(薬)学総合研究科, 講師 (00404484)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAWAKI Shouichi 鹿児島大学, 医歯(薬)学総合研究科, 教授 (80295807)
NAGAYAMA Kunihiro 鹿児島大学, 医学部・歯学部附属病院, 助教 (60583458)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 胃 / 消化管ホルモン / 自律神経機能 / 運動機能 / 歯科矯正学 / 咀嚼 / 消化管運動 / 自律神経 |
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| Outline of Final Research Achievements |
Because various mastication-related factors influence gastric activity, the functional relationship between mastication and gastric function has not been fully elucidated. To investigate the influence of mastication on gastric emptying and motility, we conducted a randomized trial to compare the effects of mastication on gastric emptying and gastric myoelectrical activity under conditions that excluded the influences of food comminution, taste, and olfaction. Gastric emptying was significantly delayed in the ‘ingestion with mastication’group. Gastric myoelectrical activity was significantly suppressed during mastication and increased gradually in the post-mastication phase. A decrease in the high-frequency power of heart rate variability was observed coincidentally with gastric myoelectrical activity suppression. These findings suggest that initial gastric emptying is suppressed by mastication, and that the suppression is caused by mastication-induced inhibition of gastric activity.
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Report
(4 results)
Research Products
(20 results)
